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SPEN encodes a hormone inducible transcriptional repressor.
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Human Polyclonal SPEN Primary Antibody pour ELISA - ABIN251251
Hiriart, Gruffat, Buisson, Mikaelian, Keppler, Meresse, Mercher, Bernard, Sergeant, Manet: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. dans The Journal of biological chemistry 2005
Human Polyclonal SPEN Primary Antibody pour ICC, IF - ABIN4355627
McHugh, Chen, Chow, Surka, Tran, McDonel, Pandya-Jones, Blanco, Burghard, Moradian, Sweredoski, Shishkin, Su, Lander, Hess, Plath, Guttman: The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. dans Nature 2015
The authors demonstrate that RBM15 (Montrer RBM15 Anticorps) is methylated by protein arginine methyltransferase 1 (PRMT1 (Montrer PRMT1 Anticorps)) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4 (Montrer CNOT4 Anticorps)).
SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha (Montrer ESR1 Anticorps)-positive breast cancers.
SPEN mutations were associated with diffuse large B-cell lymphoma with hepatitis C virus infection.
OTT1 regulates the alternative splicing of Mpl (Montrer MPL Anticorps)-TR, a truncated isoform of c-Mpl (Montrer MPL Anticorps), which modulates Thrombopoietin (Montrer THPO Anticorps)-mediated signaling.
Phosphorylation of the CK2 site on SMRT significantly increased affinity for SHARP.
RBM15 does indeed play a critical role in the survival of chronic myelogenous leukemia (CML) cells, which may have potential application in designing molecular therapies for CML treatment.
both Rbm15 (Montrer RBM15 Anticorps) and the leukemogenic Rbm15 (Montrer RBM15 Anticorps)-Mkl1 (Montrer MKL1 Anticorps) fusion protein interact with the Setd1b (Montrer SETD1B Anticorps) histone H3 (Montrer HIST3H3 Anticorps)-Lys4 methyltransferase
These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology.
A four-way variant translocation originating the RBM15 (Montrer RBM15 Anticorps)-MKL1 (Montrer MKL1 Anticorps) fusion gene is associated with acute megakaryoblastic leukemia.
HHV-8 ORF57 interacts with RBM15 (Montrer RBM15 Anticorps) and OTT3 (Montrer RBM15B Anticorps) to promote expression of viral intronless genes.
Spenito (Montrer RBM15 Anticorps), a small Spen family member, counteracted Spen function in fat regulation. Finally, mouse Spen and Spenito (Montrer RBM15 Anticorps) transcript levels scaled directly with body fat in vivo, suggesting a conserved role in fat liberation and catabolism. This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfunction.
Spen is required for gene repression by Xist. Spen is not required for Xist RNA localization and the recruitment of chromatin modifications.
Spen is required for Xist-mediated silencing.
results suggest that Xist silences transcription by directly interacting with SHARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X chromosome
MINT forms a high affinity complex with CSL (Montrer SMPX Anticorps); the domains of MINT and CSL (Montrer SMPX Anticorps) that are necessary and sufficient for complex formation are delineated
MINT plays an important role in tooth development, in particular, epithelial morphogenesis
Notch1 (Montrer NOTCH1 Anticorps) in concert with Notch2 (Montrer NOTCH2 Anticorps) contributes to the morphogenesis of renal vesicles into S-shaped bodies in a RBP-J (Montrer RBPJ Anticorps)-dependent manner.
Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch (Montrer NOTCH1 Anticorps) for binding to a DNA binding protein (Montrer HSF4 Anticorps) RBP-J (Montrer RBPJ Anticorps) and suppressed the transactivation activity of Notch (Montrer NOTCH1 Anticorps) signaling.
Stra13, Dec and Sharp (Mint) bHLH repressors are dynamically regulated during mammary gland development and may function to regulate apoptosis
MINT enhances Runx2 (Montrer RUNX2 Anticorps) activation of multiprotein complexes assembled by the OCFRE
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.
spen homolog, transcriptional regulator (Drosophila)
, SMART/HDAC1 associated repressor protein
, RNA-binding motif protein 15
, one twenty two protein
, one twenty-two
, one-twenty two protein 1
, putative RNA-binding protein 15
, Msx2 interacting nuclear target (MINT) homolog
, SMART/HDAC1-associated repressor protein
, msx2-interacting protein
, nuclear receptor transcription cofactor
, Msx2 interacting nuclear target protein