anti-Sphingosine Kinase 1 (SPHK1) Anticorps

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. De plus, nous expédions Sphingosine Kinase 1 Protéines (15) et Sphingosine Kinase 1 Kits (10) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
Comment commander chez anticorps-enligne
  • +33 (0)1 76 63 32 65
  • +33 (0)1 74 18 08 22
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top anti-Sphingosine Kinase 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 204 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, WB ABIN308402 (2µg/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Lapin Inconjugué EIA, WB The anti-SphK1 Pab is used in Western blot (Lane 2) to detect c-myc-tagged SphK1 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 1). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). Western blot analysis of anti-hSPHK1-M1 Pab in 293 cell line lysates transiently transfected with the SPHK1 gene (2 µg/lane). hSPHK1-M1(arrow) was detected using the purified Pab (1:60 dilution). 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué WB The anti-SphK1 Pab (ABIN391345) is used in Western blot (Lane 2) to detect c-myc-tagged SphK1 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 1). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). Western blot analysis of anti-hSPHK1-M1 Pab (ABIN391345) in 293 cell line lysates transiently transfected with the SPHK1 gene (2 µg/lane). hSPHK1-M1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué IHC (p), WB The anti-SPHK1 Pab (ABIN391346) is used in Western blot to detect SPHK1 in mouse kidney tissue lysate. Western blot analysis of anti-SPHK1 Antibody (Center) (ABIN391346) in 293 cell line lysates (35 µg/lane). SPHK1 (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of anti-SPHK1 Antibody (N-term) in K562 cell line lysates (35 µg/lane). SPHK1 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Mouse heart lysates probed with SPHK1 Polyclonal Antibody, unconjugated  at 1:30 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 90 minutes at 37°C. 100 μL Connectez-vous pour afficher 9 to 12 Days
315,94 €
Détails
Humain Chèvre Inconjugué EIA, WB 20 μg Connectez-vous pour afficher 8 to 10 Days
220,00 €
Détails
Souris Lapin Inconjugué WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
594,00 €
Détails
Humain Lapin Inconjugué WB Western blot analysis of anti-SPHK1 Antibody (N-term P74)(ABIN391347) in K562 cell line lysates (35 µg/lane). SPHK1(arrow) was detected using the purified polyclonal antibody. Western blot analysis of SPHK1 (arrow) using rabbit polyclonal SPHK1 Antibody (N-term P74) (ABIN391347). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SPHK1 gene. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: Sphingosine Kinase 1/SPHK1 Antibody [NBP1-02310] - (2ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails

SPHK1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , , , ,
, ,
,
, , , , , , , , , , , , , , , , , , ,
Mouse (Murine) , , ,
, ,
,
, , , , , , , , , , , , , , , ,
Rat (Rattus) , ,
,

, , , , , , , , , , , , , , , ,

anti-Sphingosine Kinase 1 Anticorps mieux référencés

  1. Human Polyclonal SPHK1 Primary Antibody pour IHC (p), WB - ABIN391346 : Nayak, Huo, Kwang, Pushparaj, Kumar, Ling, Dheen: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. dans Neuroscience 2010 (PubMed)
    Show all 17 references for 391346

  2. Human Polyclonal SPHK1 Primary Antibody pour EIA, WB - ABIN359437 : Nava, Lacana, Poulton, Liu, Sugiura, Kono, Milstien, Kohama, Spiegel: Functional characterization of human sphingosine kinase-1. dans FEBS letters 2000 (PubMed)
    Show all 5 references for 359437

  3. Human Polyclonal SPHK1 Primary Antibody pour EIA, WB - ABIN359439 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... dans Nature genetics 2003 (PubMed)
    Show all 4 references for 359439

  4. Human Polyclonal SPHK1 Primary Antibody pour WB - ABIN391345 : Hayashi, Nakagami, Takami, Koriyama, Mori, Tamai, Sun, Nagao, Morishita, Kaneda: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. dans Arteriosclerosis, thrombosis, and vascular biology 2009 (PubMed)
    Show all 2 references for 391345

  5. Human Polyclonal SPHK1 Primary Antibody pour IF (p), IHC (p) - ABIN748598 : Tani, Tabuchi, Hara: Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea. dans Neurotoxicity research 2016 (PubMed)
    Show all 2 references for 748598

  6. Human Polyclonal SPHK1 Primary Antibody pour ELISA, WB - ABIN314839 : Igarashi, Okada, Hayashi, Fujita, Jahangeer, Nakamura: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. dans The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 314839

  7. Human Polyclonal SPHK1 Primary Antibody pour WB - ABIN391347 : Di, Kawamura, Gao, Tang, Berdyshev, Vogel, Zhao, Sharma, Bachmaier, Xu, Malik: A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. dans The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for 391347

  8. Human Polyclonal SPHK1 Primary Antibody pour EIA, WB - ABIN782886 : Kohama, Olivera, Edsall, Nagiec, Dickson, Spiegel: Molecular cloning and functional characterization of murine sphingosine kinase. dans The Journal of biological chemistry 1998 (PubMed)

  9. Human Polyclonal SPHK1 Primary Antibody pour ELISA, WB - ABIN308402 : Kase, Hattori, Jojima, Okayasu, Tomizawa, Suzuki, Banba, Monden, Satoh, Akimoto, Kasai: Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. dans Life sciences 2007 (PubMed)

  10. Mouse (Murine) Polyclonal SPHK1 Primary Antibody pour WB - ABIN4620349 : Kihara, Ikeda, Kariya, Lee, Lee, Igarashi: Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. dans The Journal of biological chemistry 2003 (PubMed)

Plus d’anticorps contre Sphingosine Kinase 1 partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 (Montrer KCNN2 Anticorps) are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (Montrer MBTPS1 Anticorps) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Rabbit Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (Montrer MBTPS1 Anticorps) system activates in parallel to viral replication and the inflammatory process induced by the virus.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. we identified sphingosine kinase 1 (SPHK1) as a novel target of miR (Montrer MLXIP Anticorps)-506, the expression of which inhibited the SPHK1/Akt (Montrer AKT1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway, which is activated in pancreatic cancer. High SPHK1 expression was significantly associated with poor survival in a large cohort of pancreatic cancer specimens.

  2. Inhibition of SPHK1 in human acute myeloid leukemia (Montrer BCL11A Anticorps) cells induces MCL1 (Montrer MCL1 Anticorps) degradation and caspase (Montrer CASP3 Anticorps)-dependent cell death.

  3. The analysis suggests that the catalytic function and regulation of SPHK1 and SPHK2 (Montrer SPHK2 Anticorps) might be dependent on their conformational mobility. (Review)

  4. our data suggest that SphK1 modulates the expression of EMT (Montrer ITK Anticorps)-related markers and cell migration by regulating the expression of p-FAK (Montrer PTK2 Anticorps) in CRC (Montrer CALR Anticorps) cells. Thus, SphK1 may play a functional role in mediating the EMT (Montrer ITK Anticorps) process in CRC (Montrer CALR Anticorps).

  5. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  6. By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.

  7. SphK1 is regulated by PDGF (Montrer PDGFA Anticorps)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (Montrer EGR1 Anticorps), promoting cell proliferation.

  8. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (Montrer MBTPS1 Anticorps) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  9. demonstrated the roles played by miR (Montrer MLXIP Anticorps)-144-3p and FN1 (Montrer FN1 Anticorps) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (Montrer F9 Anticorps)

  10. SphK1 is associated with the proliferation and invasiveness of CRC (Montrer CALR Anticorps) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (Montrer CALR Anticorps).

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.

  2. Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.

  3. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  4. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (Montrer S1PR1 Anticorps) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  5. These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (Montrer AGER Anticorps)/SphK1 signaling pathway in db/db (Montrer LEPR Anticorps) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.

  6. Keratinocyte-specific deletion of Traf2 (Montrer TRAF2 Anticorps), but not Sphk1 deficiency, disrupted TNF (Montrer TNF Anticorps) mediated NF-kappaB (Montrer NFKB1 Anticorps) and MAP kinase (Montrer MAPK1 Anticorps) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.

  7. SphK1 dependent PKC-delta (Montrer PKCd Anticorps) activation plays an important role in promoting NF-kappaB (Montrer NFKB1 Anticorps) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (Montrer PKCd Anticorps) activation might be a potential therapeutic strategy for this disease.

  8. Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (Montrer HMGB1 Anticorps) cytoplasmic translocation in liver cells.

  9. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (Montrer SCRIB Anticorps) activity in vitro and in vivo.

  10. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

Sphingosine Kinase 1 (SPHK1) profil antigène

Profil protéine

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPHK1

  • Sphingosine kinase 1 (Sk1) anticorps
  • sphingosine kinase 1 (SPHK1) anticorps
  • sphingosine kinase 1 (sphk1) anticorps
  • sphingosine kinase 1 (LOC100357790) anticorps
  • sphingosine kinase 1 (Sphk1) anticorps
  • 1110006G24Rik anticorps
  • CG1747 anticorps
  • Dmel\\CG1747 anticorps
  • F18E5.160 anticorps
  • F18E5_160 anticorps
  • Sk1 anticorps
  • sphingosine kinase 1 anticorps
  • SPHK anticorps
  • SPHK1 anticorps
  • Spk1 anticorps

Protein level used designations for SPHK1

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
Fournisseurs de qualité sélectionnés pour anti-Sphingosine Kinase 1 (SPHK1) Anticorps
Avez-vous cherché autre chose?