Sprouty Homolog 4 (Drosophila) (SPRY4) Kits ELISA

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. De plus, nous expédions SPRY4 Anticorps (83) et SPRY4 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Rat SPRY4 SPRY4 291610  
Anti-Humain SPRY4 SPRY4 81848 Q9C004
Anti-Souris SPRY4 SPRY4 24066 Q9WTP2
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Plus Kits ELISA pour SPRY4 partenaires d'interaction

Human Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Studied BAK1 (Montrer BAK1 Kits ELISA), SPRY4 and GAB2 (Montrer GAB2 Kits ELISA) SNPs in pediatric germ cell tumors(GCT (Montrer QPCT Kits ELISA)); found a variant in SPRY4 was associated with reduced risk of GCT (Montrer QPCT Kits ELISA); a variant in BAK1 (Montrer BAK1 Kits ELISA) was positively associated with GCT (Montrer QPCT Kits ELISA) with a strong estimated effect for testis tumors; and a SNP in GAB2 (Montrer GAB2 Kits ELISA) was associated with increased risk for GCT (Montrer QPCT Kits ELISA).

  2. results found that histone methylation mediated by CCAT1 could also contribute to the lower expression of SPRY4 in esophageal squamous cell carcinoma

  3. mechanistic evidence that KSRP (Montrer KHSRP Kits ELISA) promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.

  4. Polymorphisms of KITLG (Montrer KITLG Kits ELISA), SPRY4, and BAK1 (Montrer BAK1 Kits ELISA) genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome

  5. SPRY4 is involved in the development and progression of colorectal cancer.

  6. Small interfering RNA (siRNA)-mediated knockdown of SPRY4 attenuated the AREG (Montrer AREG Kits ELISA)-induced down-regulation of E-cadherin (Montrer CDH1 Kits ELISA).

  7. These findings suggest that SPRY4-IT1 plays a direct role in the regulation of metastasis and progression of osteosarcoma.

  8. Results identify the tumor suppressor SPRY4 as a novel molecular effector of MT1-MMP (Montrer MMP14 Kits ELISA) affecting melanoma cell motility.

  9. Data show that proto-oncogene (Montrer RAB1A Kits ELISA) protein B (Montrer LEPREL2 Kits ELISA)-raf (BRAF (Montrer BRAF Kits ELISA)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (Montrer JUN Kits ELISA) abundance and activation by down-regulating SPRY2 (Montrer SPRY2 Kits ELISA)/4 protein expression.

  10. Specific protein 1 (Montrer SP1 Kits ELISA) plays a crucial role in the regulation of Sprouty4 in response to serum.

Mouse (Murine) Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Irf6 (Montrer IRF6 Kits ELISA) and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 (Montrer IRF6 Kits ELISA) and RTK signaling pathway genes in human orofacial clefting populations.

  2. In the present study, it is demonstrated that Spry2 (Montrer SPRY2 Kits ELISA) and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (Montrer EPHB2 Kits ELISA) signaling.

  3. Autoregulatory loop between TGF-beta1 (Montrer TGFB1 Kits ELISA)/miR (Montrer MLXIP Kits ELISA)-411-5p/SPRY4 and p38 MAPK (Montrer MAPK14 Kits ELISA) pathway in rhabdomyosarcoma modulates proliferation and differentiation.

  4. in embryos with lower Spry2 (Montrer SPRY2 Kits ELISA);Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh (Montrer SHH Kits ELISA) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  5. We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha (Montrer TNF Kits ELISA) secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased.

  6. SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia (Montrer BCL11A Kits ELISA) subtype.

  7. In vivo analysis revealed that Spry4 regulated integrin beta3 levels in murine embryos and yolk sacs (Montrer SACS Kits ELISA).

  8. We propose that Sprouty genes(Spry2 (Montrer SPRY2 Kits ELISA) and Spry4) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.

  9. ISG15 mRNA expression and IFN-dependent antiviral responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with negative feedback regulatory roles for Spry proteins in IFN-mediated signaling.

  10. our results imply that Sprouty2 (Montrer SPRY2 Kits ELISA) and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.

SPRY4 profil antigène

Antigen Summary

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS\; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002

Gene names and symbols associated with SPRY4

  • sprouty homolog 4 (Drosophila) (Spry4) anticorps
  • sprouty homolog 4 (Drosophila) (SPRY4) anticorps
  • sprouty homolog 4 (SPRY4) anticorps
  • sprouty (Drosophila) homolog 4 (spry4) anticorps
  • sprouty homolog 4 (LOC100218545) anticorps
  • A030006O18Rik anticorps
  • HH17 anticorps
  • LOC100218545 anticorps
  • sprouty4 anticorps
  • SPRY4 anticorps

Protein level used designations for SPRY4

protein sprouty homolog 4 , sprouty-like protein 4 , sprouty homolog 4 , SPRY domain-containing protein 4 , spry-4

291610 Rattus norvegicus
427643 Gallus gallus
705836 Macaca mulatta
100195736 Salmo salar
100218545 Taeniopygia guttata
81848 Homo sapiens
24066 Mus musculus
504593 Bos taurus
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