anti-TIMP Metallopeptidase Inhibitor 2 (TIMP2) Anticorps

TIMP2 is a member of the TIMP gene family.

afficher tous les anticorps Gène GeneID UniProt
Anti-Humain TIMP2 TIMP2 7077 P16035
Anti-Rat TIMP2 TIMP2 29543 P30121
Anti-Souris TIMP2 TIMP2 21858  
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Plus d’anticorps contre TIMP Metallopeptidase Inhibitor 2 partenaires d’interaction

Human TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. High TIMP2 expression is associated with acute kidney injury.

  2. High TIMP2 expression is associated with acute kidney injury.

  3. expression of TIMP2 was inversely associated with miR (Montrer MLXIP Anticorps)-106a in nodule tissues. Apoptotic body was also seen under electron microscope accompanied by silencing of miR (Montrer MLXIP Anticorps)-106a. Together, this data indicated that miR (Montrer MLXIP Anticorps)-106a may act as an oncogene (Montrer RAB1A Anticorps) and contribute to gastric cancer development.

  4. Data show that the mean values for TIMP1 (Montrer TIMP1 Anticorps), TIMP2 and MMP2 (Montrer MMP2 Anticorps) were lower in survivors, MMP9 (Montrer MMP9 Anticorps) was higher in survivors.

  5. Urine [TIMP-2]*[IGFBP7 (Montrer IGFBP7 Anticorps)] is a promising candidate for early detection of AKI, especially in ruling-out AKI

  6. We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7 (Montrer MMP7 Anticorps), MMP-10 (Montrer MMP10 Anticorps) and TIMP-1 (Montrer TIMP1 Anticorps) correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease. MMP-10 (Montrer MMP10 Anticorps), MMP-7 (Montrer MMP7 Anticorps), TIMP-1 (Montrer TIMP1 Anticorps), TIMP-2 were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively.

  7. At hospital admission, all viral gastroenteritis (GE) patients viral gastroenteritis (GE) patients demonstrated increased MMP-9 (Montrer MMP9 Anticorps) and decreased MMP-2 (Montrer MMP2 Anticorps) and TIMP-2 serum levels; kinetics of serum MMP-2 (Montrer MMP2 Anticorps), MMP-9 (Montrer MMP9 Anticorps), and TIMP-2 levels were similar among the viral GE patients but distinct from bacterial enteritis patients; involvement of MMPs and TIMPs in the pathophysiology of gastrointestinal symptoms likely varies depending on the

  8. Meta-analysis indicated that urinary [TIMP-2].[IGFBP7 (Montrer IGFBP7 Anticorps)] may be a reliable biomarker for the early detection of acute kidney injury in adults.

  9. Results show that resistant hypertension was associated with higher TIMP-2 levels and low MMP-2 (Montrer MMP2 Anticorps)/TIMP-2 ratio, suggesting that these regulators of ECM (Montrer MMRN1 Anticorps) remodeling play a key role in blood pressure control in this high-risk subset of hypertensive individuals.

  10. TIMP-2 is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 (Montrer IGFBP7 Anticorps) is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin. In human kidney tissue, strong staining of IGFBP7 (Montrer IGFBP7 Anticorps) was seen in the luminal brush-border region of a subset of proximal tubule cells, and TIMP-2 stained intracellularly in distal tubules.

Cow (Bovine) TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. Data indicate the involvement of PKC-alpha (Montrer PKCa Anticorps) in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB (Montrer NFKB1 Anticorps)-MT1-MMP (Montrer MMP14 Anticorps)-dependent and -independent pathway.

  2. A differential pattern of matrix metalloproteinase-2 (Montrer MMP2 Anticorps) and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.

  3. MMP-14 (Montrer MMP14 Anticorps), MMP-2 (Montrer MMP2 Anticorps) and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  4. Results describe distinct changes in expression of MMP2 (Montrer MMP2 Anticorps), MMP14 (Montrer MMP14 Anticorps), and the metallopeptidase (Montrer ECEL1 Anticorps) inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.

  5. Production of TIMP-1 (Montrer TIMP1 Anticorps) was augmented by IL-1alpha, TNFalpha (Montrer TNF Anticorps), and hepatocyte growth factor (Montrer HGF Anticorps) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.

  6. the different temporal expression patterns of TIMP-1 (Montrer TIMP1 Anticorps) and TIMP-2 suggest that TIMP-1 (Montrer TIMP1 Anticorps) may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance

  7. Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle

  8. Results describe the isolation of matrix metalloproteinase 2 (MMP-2 (Montrer MMP2 Anticorps)) from the MMP-2 (Montrer MMP2 Anticorps)/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 (Montrer MMP2 Anticorps) and the complex itself.

  9. oxidants inactivate TIMP-2, and the resulting activation of MMP-2 (Montrer MMP2 Anticorps) subsequently inhibits Na+ dependent Ca2 (Montrer CA2 Anticorps)+ uptake in the microsomes

  10. TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

Mouse (Murine) TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. the protein expression levels of TIMP-2 and PBEF (Montrer NAMPT Anticorps) in cloned placentae, were examined.

  2. demonstrate that TIMP-2 plays a greater protective role than TIMP-1 (Montrer TIMP1 Anticorps) during the pathogenesis of atherosclerosis

  3. Further investigation of MMP2 (Montrer MMP2 Anticorps) inhibitors of TIMP2/TIMP4 (Montrer TIMP4 Anticorps) showed an upregulated TIMP2 expression, but not TIMP4 (Montrer TIMP4 Anticorps). low-dose pre-radiation attenuates the skin inflammation and ROS (Montrer ROS1 Anticorps) production induced by medium-dose UV radiation

  4. TIMP2 and TIMP3 (Montrer TIMP3 Anticorps) play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  5. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (Montrer MAPK14 Anticorps) signaling pathway.

  6. High TIMP2 expression is associated with liver fibrosis.

  7. TIMP2 promotes kidney injury through metalloproteinase (MMP)2 (Montrer MMP2 Anticorps) activation

  8. Gene expression of Mmp-12 (Montrer MMP12 Anticorps) and Mmp-13 (Montrer MMP13 Anticorps), and Timp-1 (Montrer TIMP1 Anticorps) was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2 (Montrer MMP2 Anticorps), and Mmp-9 (Montrer MMP9 Anticorps) expression was modest.

  9. Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta (Montrer TGFB1 Anticorps), PAI-1 (Montrer SERPINE1 Anticorps) and RAGE (Montrer AGER Anticorps) in diabetic db/db (Montrer LEPR Anticorps) cells.

  10. This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI.

Xenopus laevis TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. overexpression of TIMP-2 N- and C-terminal domains results in severe developmental defects and death, as well as unique changes in MMP-2 (Montrer MMP2 Anticorps) and -9 expression, indicating that the individual domains may regulate MMPs through distinct mechanisms

  2. characterization of Xenopus tissue inhibitor of metalloproteinases-2

TIMP Metallopeptidase Inhibitor 2 (TIMP2) profil antigène

Profil protéine

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Gene names and symbols associated with TIMP2

  • TIMP metallopeptidase inhibitor 2 (TIMP2) anticorps
  • TIMP metallopeptidase inhibitor 2 (Timp2) anticorps
  • tissue inhibitor of metalloproteinase 2 (Timp2) anticorps
  • TIMP metallopeptidase inhibitor 2 (timp2) anticorps
  • tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) anticorps
  • Metalloproteinase inhibitor 2 (timp2) anticorps
  • CSC-21K anticorps
  • D11Bwg1104e anticorps
  • DDC8 anticorps
  • MGC84288 anticorps
  • MGC108274 anticorps
  • TIMP-2 anticorps
  • timp2 anticorps

Protein level used designations for TIMP2

TIMP-2 , metalloproteinase inhibitor 2 , tissue inhibitor of metalloproteinase 2 , tissue inhibitor of metalloproteinases 2 , tissue inhibitor of matrix metalloproteinase-2 , tissue inhibitor of metalloproteinase-2 , collagenase inhibitor , tissue inhibitor of mettaloproteinase 2 , TIMP metallopeptidase inhibitor 2 , Metalloproteinase inhibitor 2

GENE ID SPECIES
7077 Homo sapiens
29543 Rattus norvegicus
374178 Gallus gallus
403633 Canis lupus familiaris
282093 Bos taurus
21858 Mus musculus
447572 Xenopus laevis
548477 Xenopus (Silurana) tropicalis
574357 Macaca mulatta
100196250 Salmo salar
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