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TRAF4 encodes a member of the TNF receptor associated factor (TRAF) family. De plus, nous expédions TRAF4 Protéines (5) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 79 products:
Dog (Canine) Monoclonal TRAF4 Primary Antibody pour IF, WB - ABIN968221
Bièche, Tomasetto, Régnier, Moog-Lutz, Rio, Lidereau: Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. dans Cancer research 1996
Show all 2 Pubmed References
Human Polyclonal TRAF4 Primary Antibody pour IHC, IHC (p) - ABIN4287953
Wang, Bledsoe, Graham, Asmann, Viswanatha, Lewis, Lewis, Chou, Yaszemski, Jen, Westendorf, Oliveira: Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma. dans Nature genetics 2014
Cow (Bovine) Polyclonal TRAF4 Primary Antibody pour IHC, IHC (p) - ABIN4361681
Krajewska, Krajewski, Zapata, Van Arsdale, Gascoyne, Berern, McFadden, Shabaik, Hugh, Reynolds, Clevenger, Reed: TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. dans The American journal of pathology 1998
miR (Montrer MLXIP Anticorps)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 (Montrer NCOA1 Anticorps) downstream of MEK (Montrer MAP2K1 Anticorps)-C/EBP (Montrer CEBPA Anticorps)-mediated leptin (Montrer LEP Anticorps) and insulin (Montrer INS Anticorps) signaling, and that insulin (Montrer INS Anticorps) and/or leptin (Montrer LEP Anticorps) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (Montrer CALR Anticorps).
TRAF4 expression is higher in mastocytosis patients with food hypersensitivity in their medical history, while B3GAT1 (Montrer B3GAT1 Anticorps) expression is lower in mastocytosis patients with insect venom allergy in history
Determined the crystal structure of TRAF (Montrer TRAF1 Anticorps) domain of TRAF4 (residues 292-466) at 2.60 A resolution by X-ray crystallography method. The trimericly assembled TRAF4 resembles a mushroom shape, containing a super helical "stalk" which is made of three right-handed intertwined alpha helixes and a C-terminal "cap", which is divided at residue L302 as a boundary.
TRAF4 may promote oral squamous carcinoma cell growth, invasion and migration by Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) pathway.
There was a significant positive correlation between TRAF2 (Montrer TRAF2 Anticorps) and TRAF4 expression levels in malignant pleural effusion cells
The TRAF4-ERK (Montrer IL17A Anticorps)5 is a dominant pathway in human skin squamous cell carcinoma.
Data showed that TRAF4 was highly expressed in non-small cell lung cancer (NSCLC) cells, and miR (Montrer MLXIP Anticorps)-370 overexpression significantly inhibited its expression. These results suggest that TRAF4 serves as an oncogene (Montrer RAB1A Anticorps) in NSCLC.
these results suggest that TRAF4 promoted colon cancer cell growth and invasion
Expression of tumor necrosis factor (Montrer TNF Anticorps) receptor-assicated factor 4 correlates with expression of Girdin (Montrer CCDC88A Anticorps) and promotes nuclear translocation of Girdin (Montrer CCDC88A Anticorps) in breast cancer
p70s6k (Montrer RPS6KB1 Anticorps)/S6 signaling pathway played an important role in the promoting function of TRAF4 on cell proliferation. This work suggests a new direction for understanding the oncogenic function of TRAF4 in breast cancer.
A novel IL-17 (Montrer IL17A Anticorps) signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 (Montrer MAPK7 Anticorps) axis.
Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2 (Montrer SMURF2 Anticorps), to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (Montrer DAZAP2 Anticorps)).
Like IKKalpha (Montrer CHUK Anticorps), TRAF4 is atypical within its family because it is the only TRAF (Montrer TRAF1 Anticorps) family member to negatively regulate innate immune signaling. IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation.
Report divergent effects of p47(phox) phosphorylation at S303-4 or S379 on tumor necrosis factor-alpha (Montrer TNF Anticorps) signaling via TRAF4 and MAPK (Montrer MAPK1 Anticorps) in endothelial cells.
These results provide conclusive evidence for the pivotal contribution of TRAF4 to myelination.
enhances TNF-alpha (Montrer TNF Anticorps) translation
A novel motif in the Crohn's disease susceptibility protein, NOD2 (Montrer NOD2 Anticorps), allows TRAF4 to down-regulate innate immune responses.
Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.
TRAF4 may play a role in p53 (Montrer TP53 Anticorps)-mediated proapoptotic signaling in the response to cellular stress
MEKK4 (Montrer MAP3K4 Anticorps) is the MAPK (Montrer MAPK1 Anticorps) kinase kinase for TRAF4 regulation of the JNK (Montrer MAPK8 Anticorps) pathway
cloning of two zebrafish orthologs of the human traf4, traf4a and traf4b; during embryogenesis, traf4b expression is present in a weak ubiquitous manner
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
, RING finger protein 83
, cysteine-rich domain associated with RING and Traf domains protein 1
, cysteine-rich domain associated with ring and TRAF domain
, malignant 62
, metastatic lymph node gene 62 protein
, tumor necrosis receptor-associated factor 4A
, TNF receptor-associated factor 4
, cysteine-rich motif associated to RING and Traf domains protein 1
, LOW QUALITY PROTEIN: TNF receptor-associated factor 4