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The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. De plus, nous expédions TRPM2 Protéines (6) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 81 products:
Mouse (Murine) Polyclonal TRPM2 Primary Antibody pour ICC, IHC (fro) - ABIN259658
Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. dans Neurotoxicology 2010
Show all 8 references for ABIN259658
Human Polyclonal TRPM2 Primary Antibody pour ICC, IHC (fro) - ABIN153042
Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. dans Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Polyclonal TRPM2 Primary Antibody pour ICC, IF - ABIN153041
Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. dans Journal of medicinal chemistry 2013
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Mouse (Murine) Polyclonal TRPM2 Primary Antibody pour ICC, IF - ABIN4362934
Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. dans Scientific reports 2015
Cow (Bovine) Polyclonal TRPM2 Primary Antibody pour IHC, WB - ABIN2781840
Hecquet, Ahmmed, Vogel, Malik: Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability. dans Circulation research 2008
Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .
heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (Montrer TRPC3 Anticorps) or TRPC7 protein induce enhanced receptor-activated Ca(2 (Montrer CA2 Anticorps)+) influx that may lead to dysregulated cell growth in ADPKD
Study demonstrate that PRL (Montrer PRL Anticorps) is necessary for the survival of (retinal pigment epithelium) RPE (Montrer RPE Anticorps) under normal and advancing age conditions and, identified SIRT2 (Montrer SIRT2 Anticorps) and TRPM2 (Montrer CLU Anticorps) as molecular targets for the antioxidant and antiapoptotic actions of PRL (Montrer PRL Anticorps) in the RPE (Montrer RPE Anticorps).
TRPM2 (Montrer CLU Anticorps) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (Montrer BCL2 Anticorps) dependent manner
Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) chan (Montrer TRPM3 Anticorps)nel wer (Montrer CLU Anticorps)e more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.
This is expected to provide a basis for inhibiting TRPM2 (Montrer CLU Anticorps) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.
In a transgenic mouse model of Alzheimer's disease, TRPM2 (Montrer CLU Anticorps) was involved in neuronal toxicity and memory impairment.
These findings shed new light on the evolution of TRPM2 (Montrer CLU Anticorps) and establish nvTRPM2 as a promising tool to decipher its complex gating mechanisms.
we report here a novel effect promoted by TRPM2 (Montrer CLU Anticorps), where it functions to minimize DNA damage and thus may have a role in the protection of genomic DNA in breast cancer cells.
The HDACi-elicited upregulation of TRPM2 (Montrer CLU Anticorps) expression.
TRPM2 (Montrer CLU Anticorps) actively regulates the phosphorylation of GSK-3 (Montrer GSK3b Anticorps) in the brain.
The degradation of zonula occludens-1 (ZO-1 (Montrer TJP1 Anticorps)), and claudin-2 (Montrer CLDN2 Anticorps) exhibited a great dependence on the activation of the transient receptor potential melastatin (Montrer TRPM1 Anticorps) (TRPM) 2 (Montrer CLU Anticorps) channel, phospholipase Cgamma1 (PLCgamma1 (Montrer PLCG1 Anticorps)) and the protein kinase (Montrer CDK7 Anticorps) Calpha (Montrer PRKACA Anticorps) (PKCalpha (Montrer PKCa Anticorps)) signaling cascade.
Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (Montrer TRPM3 Anticorps) (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs (Montrer NPS Anticorps)) exposure than those from senescent ones.
TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (Montrer PARP1 Anticorps) pathway
mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour
findings provide compelling evidence that F. tularensis catalase (Montrer CAT Anticorps) restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2 (Montrer CA2 Anticorps)+) signaling and limit host immune function.
TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain.
The findings provide evidence for a mechanism by which Abeta (Montrer APP Anticorps) impairs neurovascular regulation and suggest that TRPM2 channels are a potential therapeutic target to counteract cerebrovascular dysfunction in Alzheimer's dementia.
Neointimal hyperplasia was substantially reduced in Trpm2 knockout mice.
endogenous redox signals in pancreatic beta cells elevate insulin (Montrer INS Anticorps) secretion via TRPM2 sensitization and activity at body temperature
These results provide the first evidence to show a critical role for TRPM2 channel activation during reperfusion in the delayed increase in the [Zn(2+)]c and CA1 (Montrer CA1 Anticorps) pyramidal neuronal death.
Postischemic neovascularization in mice required reactive oxygen species generation in endothelial cells and resultant TRPM2 activation.
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
transient receptor potential cation channel, subfamily M, member 2
, transient receptor potential cation channel, subfamily C, member 7
, transient receptor potential cation channel, subfamily C, member 7-like
, short transient receptor potential channel 7-like
, transient receptor potential cation channel subfamily M member 2-like
, transient receptor potential channel subfamily C member 7
, estrogen-responsive element-associated gene 1 protein
, long transient receptor potential channel 2
, transient receptor potential cation channel subfamily M member 2
, transient receptor potential channel 7
, transient receptor protein 7
, transient receptor potential melastatin family 2