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The protein encoded by TRIM55 contains a RING zinc finger, a motif known to be involved in protein-protein interactions. De plus, nous expédions TRIM55 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal TRIM55 Primary Antibody pour WB - ABIN2781240
Lange, Xiang, Yakovenko, Vihola, Hackman, Rostkova, Kristensen, Brandmeier, Franzen, Hedberg, Gunnarsson, Hughes, Marchand, Sejersen, Richard, Edström, Ehler, Udd, Gautel: The kinase domain of titin controls muscle gene expression and protein turnover. dans Science (New York, N.Y.) 2005
Human Polyclonal TRIM55 Primary Antibody pour ELISA, WB - ABIN184953
Centner, Yano, Kimura, McElhinny, Pelin, Witt, Bang, Trombitas, Granzier, Gregorio, Sorimachi, Labeit: Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. dans Journal of molecular biology 2001
The study suggested that the porcine MuRF2 and MuRF3 (Montrer TRIM54 Anticorps) genes are involved in the muscle growth and development.
MuRF2 regulates PPARgamma1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
MuRF1 (Montrer TRIM63 Anticorps) and MuRF2 play a redundant role in regulating developmental physiologic hypertrophy, by regulating E2F (Montrer E2F1 Anticorps) transcription factors essential for normal cardiac development and by supporting E2F (Montrer E2F1 Anticorps) localization to the nucleus, but not through degradation.
results indicate that MURF2A and MURF2B proteins could participate in the molecular switch between the two ubiquitin degradative pathways.
MURF2 isoforms undergo pre- and postnatal switching and overall downregulation in developing skeletal muscle.
MURF2 expression parallels that of the autophagy-associated proteins LC3 (Montrer MAP1LC3A Anticorps), p62/SQSTM1 (Montrer SQSTM1 Anticorps) and nbr1 (Montrer NBR1 Anticorps)
Data suggest that expression of MuRF1 (Montrer TRIM63 Anticorps) is required for remodeling of type-II fibers under pathophysiological stress states, whereas MuRF1 (Montrer TRIM63 Anticorps) and MuRF2 together are required for maintenance of type-II fibers, possibly via the regulation of myozenin-1 (Montrer MYOZ1 Anticorps).
Double knockout (dKO) mice obtained by the inactivation of all four MuRF1 (Montrer TRIM63 Anticorps) and MuRF2 alleles developed extreme cardiac and milder skeletal muscle hypertrophy.
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.
tripartite motif-containing 55
, ring finger protein 29
, tripartite motif-containing protein 55-like
, muscle specific ring finger 2
, muscle-specific RING finger protein 2
, tripartite motif-containing protein 55