anti-Troponin T2, Cardiac (TNNT2) Anticorps

The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. De plus, nous expédions Cardiac Troponin T2 Kits (72) et Cardiac Troponin T2 Protéines (36) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TNNT2 7139 P45379
TNNT2 24837 P50753
TNNT2 21956 P50752
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Top anti-Cardiac Troponin T2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 381 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Poulet Souris Inconjugué IF, IHC (p) 0.1 mg Connectez-vous pour afficher 8 to 10 Days
495,00 €
Détails
Humain Lapin Inconjugué EIA, WB TNNT2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the TNNT2 antibody detected the TNNT2 protein (arrow). 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Cat Souris Inconjugué EIA, IHC (p), IP, WB 50 μg Connectez-vous pour afficher 8 to 10 Days
517,00 €
Détails
Boeuf (Vache) Souris Inconjugué EIA, WB   0.2 mg Connectez-vous pour afficher 8 to 10 Days
363,00 €
Détails
Humain Souris Inconjugué EIA, IHC (p) 0.25 mg Connectez-vous pour afficher 8 to 10 Days
517,00 €
Détails
Humain Chèvre Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Souris Inconjugué IA, WB   0.2 mg Connectez-vous pour afficher 3 to 5 Days
265,00 €
Détails
Humain Souris Inconjugué EIA, WB 0.2 mg Connectez-vous pour afficher 8 to 10 Days
396,00 €
Détails
Humain Souris Inconjugué EIA, FACS, WB 0.1 mL Connectez-vous pour afficher 8 to 10 Days
473,00 €
Détails

TNNT2 Anticorps par réactivité, application, clonalité et conjugué

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anti-Cardiac Troponin T2 Anticorps mieux référencés

  1. Human Polyclonal Cardiac Troponin T2 Primary Antibody pour EIA, WB - ABIN951043 : Millat, Chanavat, Créhalet, Rousson: Development of a high resolution melting method for the detection of genetic variations in hypertrophic cardiomyopathy. dans Clinica chimica acta; international journal of clinical chemistry 2010 (PubMed)
    Show all 3 references for 951043

  2. Cow (Bovine) Polyclonal Cardiac Troponin T2 Primary Antibody pour WB - ABIN2776953 : Klaassen, Probst, Oechslin, Gerull, Krings, Schuler, Greutmann, Hürlimann, Yegitbasi, Pons, Gramlich, Drenckhahn, Heuser, Berger, Jenni, Thierfelder: Mutations in sarcomere protein genes in left ventricular noncompaction. dans Circulation 2008 (PubMed)

  3. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody pour IF, IHC (p) - ABIN180606 : Malouf, McMahon, Oakeley, Anderson: A cardiac troponin T epitope conserved across phyla. dans The Journal of biological chemistry 1992 (PubMed)

  4. Human Monoclonal Cardiac Troponin T2 Primary Antibody pour EIA, FACS - ABIN1105666 : Hershberger, Pinto, Parks, Kushner, Li, Ludwigsen, Cowan, Morales, Parvatiyar, Potter: Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. dans Circulation. Cardiovascular genetics 2009 (PubMed)

  5. Human Monoclonal Cardiac Troponin T2 Primary Antibody pour IA, WB - ABIN265695 : Qiao, Tang, Munske, Dutta, Ivory, Dong: Enhanced fluorescence anisotropy assay for human cardiac troponin I and T detection. dans Journal of fluorescence 2011 (PubMed)

Plus d’anticorps contre Cardiac Troponin T2 partenaires d’interaction

Human Troponin T2, Cardiac (TNNT2) interaction partners

  1. Higher postoperative concentrations of high-sensitivity troponin T are independently associated with all-cause mortality in patients undergoing on-pump cardiac surgery.

  2. variants in TNNT2 and BAG3 (Montrer BAG3 Anticorps) are associated with a high propensity to life-threatening cardiomyopathy presenting from childhood and young adulthood.

  3. Binding of the MBNL (Montrer MBNL1 Anticorps) zinc fingers to cardiac troponin T pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.

  4. The measurement of high-sensitivity cardiac troponin T plasma concentration within large nationally-representative surveys such as the Health Survey for England is feasible.

  5. Data suggest that modulation of structural dynamics far from the regulatory Ca2 (Montrer CA2 Anticorps)+-binding site is the underlying molecular mechanism for many TNNC1 (Montrer TNNC1 Anticorps) mutations in patients with hypertrophic cardiomyopathies or familial hypertrophic cardiomyopathies; many mutations affect balance between open and closed conformations; troponin I switch peptide [TnI (Montrer TNNI2 Anticorps)(SW)] switch peptide binds to TNNC1 (Montrer TNNC1 Anticorps) and stabilizes the open TNNC1 (Montrer TNNC1 Anticorps) conformation.

  6. Data suggest that the tropomyosin (Montrer TPM2 Anticorps) overlap region structure and function are affected differentially by a point mutation in cardiac tropomyosin (TPM1, D230N) that is associated with dilated cardiomyopathy as compared to a point mutation in cardiac troponin T (TNNT2, R92L) that is associated with hypertrophic cardiomyopathy.

  7. High T2-weighted signal intensity on cine MRI is associated with elevated troponin T in hypertrophic cardiomyopathy.

  8. The high negative predictive value of preoperative hs-cTnT and NT-proBNP suggest usefulness as a "rule-out" test to confirm low risk of postoperative Myocardial Infarction

  9. Generated is a gene-targeted knock-in murine model of the autosomal dominant Arg141Trp (R141W) mutation in human Tnnt2. Tnnt2 R141W mutation causes a Ca2 (Montrer CA2 Anticorps)+ desensitization and mice adapt by increasing Ca2 (Montrer CA2 Anticorps)+-transient amplitudes, which impairs Ca2 (Montrer CA2 Anticorps)+ handling dynamics, metabolism and responses to beta-adrenergic activation.

  10. A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.

Pig (Porcine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. Significant changes in thin filament Ca2 (Montrer CA2 Anticorps)+-sensitivity, structure and kinetics are brought about through PKC (Montrer PKC Anticorps) phosphorylation of cardiac troponin T.

  2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Rabbit Troponin T2, Cardiac (TNNT2) interaction partners

  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.

Mouse (Murine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. TnTA30V mutation attenuated Ca(2 (Montrer CA2 Anticorps)+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin (Montrer MYH6 Anticorps) heavy chain but augmented these parameters against beta-myosin heavy chain (Montrer MYH7 Anticorps), suggesting divergent contractile phenotypes.

  2. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A (Montrer DYRK1A Anticorps) overexpression.

  3. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT (Montrer TNNI1 Anticorps), Ca(2 (Montrer CA2 Anticorps)+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

  4. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain (Montrer MYH7 Anticorps)

  5. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

  6. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

  7. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  8. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

  9. TnT (Montrer TNNI1 Anticorps) mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 (Montrer MYH6 Anticorps) and hypertrophic cardiomyopathy in the presence of MYH7 (Montrer MYH7 Anticorps).

  10. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

Zebrafish Troponin T2, Cardiac (TNNT2) interaction partners

  1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

  2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

  3. Tnnt1 (Montrer TNNI1 Anticorps), Tnnt2, and Tnnt3b were conserved in the central tropomyosin (Montrer TPM2 Anticorps)- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 (Montrer TNNI1 Anticorps) and Tnnt2, but not Tnnt3b.

Cardiac Troponin T2 (TNNT2) profil antigène

Profil protéine

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Gene names and symbols associated with TNNT2

  • troponin T type 2 (cardiac) (TNNT2) anticorps
  • troponin T2, cardiac (Tnnt2) anticorps
  • troponin T type 2 (cardiac) (Tnnt2) anticorps
  • troponin T type 2 (cardiac) (tnnt2) anticorps
  • troponin T2a, cardiac (tnnt2a) anticorps
  • CMH2 anticorps
  • CMPD2 anticorps
  • CT3 anticorps
  • cTnT anticorps
  • Ctt anticorps
  • CTTG anticorps
  • LVNC6 anticorps
  • RATCTTG anticorps
  • RCM3 anticorps
  • tnnt2 anticorps
  • Tnnt3 anticorps
  • Tnt anticorps
  • TnTC anticorps

Protein level used designations for TNNT2

troponin T, cardiac muscle , troponin T2, cardiac , cardiac troponin 2 , cardiac troponin T , troponin T type 2, cardiac , cardiomyopathy, dilated 1D (autosomal dominant) , cardiomyopathy, hypertrophic 2 , Troponin T cardiac , cTnT , cardiac muscle troponin T , cardiac troponin T2 , tnTc , cardiac troponin T form I , tnTC , troponin T, cardiac muscle isoforms , Troponin T, cardiac muscle , troponin T cardiac isoform , cardiac TnT , sih , silent heart

GENE ID SPECIES
493940 Felis catus
100379561 Cavia porcellus
403532 Canis lupus familiaris
7139 Homo sapiens
24837 Rattus norvegicus
398518 Xenopus laevis
396433 Gallus gallus
100622450 Sus scrofa
286816 Bos taurus
100009428 Oryctolagus cuniculus
21956 Mus musculus
58071 Danio rerio
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