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Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. De plus, nous expédions UGCG Anticorps (38) et UGCG Protéines (8) et beaucoup plus de produits pour cette protéine.
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Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma.
GCS (Montrer GCLC Kits ELISA) was upregulated in colorectal carcinoma tissues compared to control tissues.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (Montrer SGMS1 Kits ELISA)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women.
Our data demonstrates a correlation between the expression of the GCS (Montrer GCLC Kits ELISA) protein and ER-positive/HER-2 (Montrer ERBB2 Kits ELISA) negative breast cancer
our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD.
GCS (Montrer GCLC Kits ELISA) was upregulated in PTCs and might be an independent factor affecting prognosis.
Glucosylceramide synthase mRNA were reduced by 62%.
The results thus show that ARF6 (Montrer ARF6 Kits ELISA) regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels.
DOX could modulate the expression of GCS (Montrer GCLC Kits ELISA) through the Sp1 (Montrer PSG1 Kits ELISA) site of GCS (Montrer GCLC Kits ELISA) promoter in ERalpha (Montrer ESR1 Kits ELISA)-positive breast cancer cells
Ceramide glycosylation catalyzed by glucosylceramide synthase is important for cancer stem cells in drug resistance and tumorigenesis.
we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease.
These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin (Montrer INS Kits ELISA) signaling and white adipose tissue function in fasted mice.
we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells.
Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin (Montrer INS Kits ELISA) signaling.
Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.
The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase).
Data indicate that mice with cerebroside sulfotransferases (Cst (Montrer CORT Kits ELISA)) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst (Montrer CORT Kits ELISA) deficiency had lower ammonium excretion.
glycosphingolipids in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism. Ugcg inhibitors exert their effect on hepatocytes either independently of GSL (Montrer CTSA Kits ELISA) or mediated by other (liver) cell types.
Ugcg and Ugt8a (Montrer UGT8 Kits ELISA) deficient oligodendroglial did not exhibit any phenotypic or myelin structural abnormalities; abundant and structurally intact myelin can form in their absence
Shortly after birth UgcG deficient mice showed dysfunction of cerebellum and peripheral nerves, associated with structural defects
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.
, UDP-glucose ceramide glucosyltransferase b
, ceramide glucosyltransferase b
, ceramide glucosyltransferase-B
, UDP-glucose:N-acylsphingosine D-glucosyltransferase
, glucosylceramide synthase
, ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21
, UDP-glucose:ceramide glycosyltransferase