UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Kits ELISA

UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. De plus, nous expédions UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Anticorps (64) et UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Protéines (4) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Rat UPF1 UPF1 306350  
Anti-Humain UPF1 UPF1 5976 Q92900
Anti-Souris UPF1 UPF1 19704 Q9EPU0
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Plus Kits ELISA pour UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) partenaires d'interaction

Caenorhabditis elegans (C. elegans) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. results suggest that the role of SMG-5 (Montrer ZCCHC11 Kits ELISA) is to direct protein phosphatase 2A to its SMG-2 substrate

  2. SMG-2 interacts with SMG-3, SMG-3 interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3. SMG-2 preferentially associates with PTC (Montrer PTCH1 Kits ELISA)-containing mRNAs.

Human UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. Upregulation of SNHG6 regulates ZEB1 (Montrer ZEB1 Kits ELISA) expression by competitively binding miR (Montrer MLXIP Kits ELISA)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.

  2. Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.

  3. CARM1 (Montrer CARM1 Kits ELISA) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.

  4. Upf1 is a RNA helicase (Montrer DDX46 Kits ELISA) essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.

  5. Results present evidence for a critical role for Upf1 ATPase (Montrer DNAH8 Kits ELISA) activity in nonsense-mediated decay target discrimination, with preferential ATPase (Montrer DNAH8 Kits ELISA)-dependent release of Upf1 from non-target mRNAs as part of the underlying mechanism.

  6. GR and PNRC2 (Montrer PNRC2 Kits ELISA) interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation

  7. Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5 (Montrer SMG5 Kits ELISA), and Smg7 led to increased levels of viral proteins and and virus release.

  8. UPF1 gets recruited to mRNA and becomes phosphorylated before being exported to the cytoplasm as part of the mRNP.

  9. SMG6 requires UPF1 and SMG1 for nonsense-mediated mRNA decay.

  10. The study demonstrates that SMG5 (Montrer SMG5 Kits ELISA)-SMG7 and SMG6 (Montrer SMG6 Kits ELISA) exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.

Mouse (Murine) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .

  2. results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome

UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) profil antigène

Antigen Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

Gene names and symbols associated with UPF1

  • regulator of nonsense transcripts 1 (Rent1) anticorps
  • UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) anticorps
  • regulator of nonsense transcripts 1 (Tc00.1047053511317.30) anticorps
  • regulator of nonsense transcripts 1 (Tb927.5.2140) anticorps
  • regulator of nonsense transcripts 1 (TVAG_453890) anticorps
  • regulator of nonsense transcripts 1 (TVAG_237840) anticorps
  • regulator of nonsense transcripts 1 (AOR_1_1018194) anticorps
  • regulator of nonsense transcripts 1 (HPB8_739) anticorps
  • Protein SMG-2 (smg-2) anticorps
  • upf1 regulator of nonsense transcripts homolog (yeast) (upf1) anticorps
  • UPF1 regulator of nonsense transcripts homolog (yeast) (Upf1) anticorps
  • AO090012000584 anticorps
  • B430202H16Rik anticorps
  • HUPF1 anticorps
  • NORF1 anticorps
  • PNORF-1 anticorps
  • pNORF1 anticorps
  • Rent1 anticorps
  • smg-2 anticorps
  • Tb05.3C6.50 anticorps
  • Upflp anticorps
  • wu:fi40f07 anticorps
  • wu:fj48a01 anticorps
  • zgc:55472 anticorps

Protein level used designations for UPF1

regulator of nonsense transcripts 1 , ATP-dependent helicase RENT1 , UP Frameshift 1 , delta helicase , nonsense mRNA reducing factor 1 , smg-2 homolog, nonsense mediated mRNA decay factor , up-frameshift mutation 1 homolog , up-frameshift suppressor 1 homolog , yeast Upf1p homolog , Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) , mUpf1

GENE ID SPECIES
306350 Rattus norvegicus
456373 Pan troglodytes
3541249 Trypanosoma cruzi strain CL Brener
3657316 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4775578 Trichomonas vaginalis G3
5467310 Trichomonas vaginalis G3
5988051 Aspergillus oryzae RIB40
9349309 Helicobacter pylori B8
171696 Caenorhabditis elegans
406783 Danio rerio
5976 Homo sapiens
19704 Mus musculus
420119 Gallus gallus
476664 Canis lupus familiaris
532933 Bos taurus
684558 Rattus norvegicus
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