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UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. De plus, nous expédions UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Anticorps (64) et UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Protéines (4) et beaucoup plus de produits pour cette protéine.
results suggest that the role of SMG-5 (Montrer ZCCHC11 Kits ELISA) is to direct protein phosphatase 2A to its SMG-2 substrate
SMG-2 interacts with SMG-3, SMG-3 interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3. SMG-2 preferentially associates with PTC (Montrer PTCH1 Kits ELISA)-containing mRNAs.
The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.
MARVELD1 substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (Montrer RBM8A Kits ELISA). MARVELD1 promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (Montrer SMG5 Kits ELISA).
UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.
Upregulation of SNHG6 regulates ZEB1 (Montrer ZEB1 Kits ELISA) expression by competitively binding miR (Montrer MLXIP Kits ELISA)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.
Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.
CARM1 (Montrer CARM1 Kits ELISA) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.
Upf1 is a RNA helicase (Montrer DDX46 Kits ELISA) essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.
Results present evidence for a critical role for Upf1 ATPase (Montrer DNAH8 Kits ELISA) activity in nonsense-mediated decay target discrimination, with preferential ATPase (Montrer DNAH8 Kits ELISA)-dependent release of Upf1 from non-target mRNAs as part of the underlying mechanism.
GR and PNRC2 (Montrer PNRC2 Kits ELISA) interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation
Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5 (Montrer SMG5 Kits ELISA), and Smg7 led to increased levels of viral proteins and and virus release.
Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .
results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
regulator of nonsense transcripts 1
, ATP-dependent helicase RENT1
, UP Frameshift 1
, delta helicase
, nonsense mRNA reducing factor 1
, smg-2 homolog, nonsense mediated mRNA decay factor
, up-frameshift mutation 1 homolog
, up-frameshift suppressor 1 homolog
, yeast Upf1p homolog
, Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)