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UBR5 encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. De plus, nous expédions UBR5 Kits (3) et et beaucoup plus de produits pour cette protéine.
Showing 10 out of 80 products:
Human Polyclonal UBR5 Primary Antibody pour ICC, IF - ABIN151138
Nash, Chen, Salganik, Muzyczka: Identification of cellular proteins that interact with the adeno-associated virus rep protein. dans Journal of virology 2008
Show all 7 references for ABIN151138
Human Polyclonal UBR5 Primary Antibody pour IHC (p), IHC - ABIN249850
Garbow, Doherty, Schugar, Travers, Weber, Wentz, Ezenwajiaku, Cotter, Brunt, Crawford: Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. dans American journal of physiology. Gastrointestinal and liver physiology 2011
Show all 2 references for ABIN249850
Human Polyclonal UBR5 Primary Antibody pour IHC, ELISA - ABIN184976
Henderson, Russell, Hird, Muñoz, Clancy, Lehrbach, Calanni, Jans, Sutherland, Watts: EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. dans The Journal of biological chemistry 2002
Cow (Bovine) Polyclonal UBR5 Primary Antibody pour EIA, IHC (p) - ABIN1109445
Hay-Koren, Caspi, Zilberberg, Rosin-Arbesfeld: The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. dans Molecular biology of the cell 2011
Study highlights many functional biological role of UBR5 especially in cancer where it seems to be a key regulator of cell signaling. [review]
Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro
Human herpesvirus-6 U14 induces cell cycle arrest in G2/M phase by associating with a cellular protein, EDD.
Elevated metaphase RanGTP levels use Ubr5 to couple overall chromosome congression to SAC (Montrer ADCY10 Anticorps) silencing.
results confirm the role of the MLLE domain of UBR5 in substrate recruitment and suggest a potential role in regulating UBR5 ligase activity.
these observations highlight the potential role of EDD in regulating mitotic progression and the cellular response to perturbed mitosis.
Utilizing a high throughput RNAi screening approach author identified UBR5, a protein commonly amplified in breast cancer, as a novel regulator of ERalpha (Montrer ESR1 Anticorps) protein levels and transcriptional activity.
the alpha4 N-terminus binding to endogenous PP2Ac (Montrer PPP2CA Anticorps) and PABP (Montrer PABPC1 Anticorps), and the C-terminus to EDD, is reported.
These results identify EDD as a dual regulator of cell survival and cisplatin resistance and suggest that EDD is a therapeutic target for ovarian cancer.
Determined is the three-dimensional solution structure of the catalytic RING2 (Montrer RNF2 Anticorps) domain from HHARI (Montrer ARIH1 Anticorps). It shows glimpses of a HECT E3 ligase.
UBR5-mediated ATMIN (Montrer ATMIN Anticorps) ubiquitination is a vital event for ATM (Montrer ATM Anticorps) pathway selection and activation in response to DNA damage
a novel function of RIP1 (Montrer RALBP1 Anticorps) kinase involving its interaction with EDD to regulate JNK (Montrer MAPK8 Anticorps) activation and TNFalpha (Montrer TNF Anticorps) production.
Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth.
The SCF (Montrer KITLG Anticorps) E3 ligase complex containing Fbxo40 (Montrer FBXO40 Anticorps) directly ubiquitinates IRS1 (Montrer IRS1 Anticorps), and this activity is enhanced by increased tyrosine phosphorylation of IRS1 (Montrer IRS1 Anticorps).
Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors.
UBR5 can attenuate myocardin (Montrer MYOCD Anticorps) protein degradation resulting in increased myocardin (Montrer MYOCD Anticorps) protein expression without affecting myocardin (Montrer MYOCD Anticorps) mRNA expression.
Results suggest that Edd has an essential role in extraembryonic development.
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
E3 identified by differential display
, E3 ubiquitin protein ligase, HECT domain containing, 1
, E3 ubiquitin-protein ligase UBR5
, E3 ubiquitin-protein ligase, HECT domain-containing 1
, hyperplastic discs protein homolog
, progestin induced protein
, progestin-induced protein
, ubiquitin-protein ligase
, extraembryonic development