Ubiquitin Specific Peptidase 8 (USP8) Kits ELISA

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. De plus, nous expédions USP8 Anticorps (91) et USP8 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
USP8 9101 P40818
Anti-Rat USP8 USP8 296121  
Anti-Souris USP8 USP8 84092 Q80U87
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Top USP8 Kits ELISA sur anticorps-enligne.fr

Showing 7 out of 10 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 0.101 ng/mL 0.312-20 ng/mL 96 Tests Connectez-vous pour afficher 15 to 17 Days
$908.41
Détails
Humain 0.101 ng/mL 0.312 ng/mL - 20 ng/mL   96 Tests Connectez-vous pour afficher 8 to 12 Days
$766.25
Détails
Porc 0.188 ng/mL 0.313-20 ng/mL   96 Tests Connectez-vous pour afficher 12 to 14 Days
$715.00
Détails
Poulet 0.188 ng/mL 0.313-20 ng/mL   96 Tests Connectez-vous pour afficher 12 to 14 Days
$715.00
Détails
Singe 0.188 ng/mL 0.313-20 ng/mL   96 Tests Connectez-vous pour afficher 12 to 14 Days
$715.00
Détails
Cobaye 0.094 ng/mL 0.156-10 ng/mL   96 Tests Connectez-vous pour afficher 12 to 14 Days
$715.00
Détails
Lapin 75 pg/mL 125-8000 pg/mL   96 Tests Connectez-vous pour afficher 12 to 14 Days
$715.00
Détails

Plus Kits ELISA pour USP8 partenaires d'interaction

Human Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. Data indicate that USP8 functions as a novel deubiquitylase of FLIPL and inhibits extrinsic apoptosis by stabilizing FLIPL.

  2. Somatic USP8 gene mutations are a common cause of pediatric Cushing disease due to pituitary adenoma.

  3. findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 (Montrer BACE Kits ELISA) by deubiquitinating lysine 501.

  4. USP8 regulates VEGFR2 (Montrer KDR Kits ELISA) trafficking, signaling and proteolysis.

  5. Ubpy loss of function results in the accumulation of autophagosomes due to a blockade of the autophagy flux.

  6. Results show that in addition to the scaffolding function in complex formation, BRUCE (Montrer BIRC6 Kits ELISA) has an E3 ligase function to promote BRIT1 (Montrer MCPH1 Kits ELISA) deubiquitination by USP8 leading to accumulation of BRIT1 (Montrer MCPH1 Kits ELISA) at DNA double-strand break.

  7. No somatic mutations were observed in USP8 in a cohort of GH-secreting pituitary adenomas.

  8. Studies indicate that ubiquitin specific protease 8 protein (USP8) mutations contribute to adrenocorticotropic hormone (ACTH) overproduction in Cushing's disease (CD).

  9. The presence of USP8 mutations may predict favorable responses to the somatostatin (Montrer SST Kits ELISA) analog pasireotide in corticotroph adenomas of Cushing's disease.

  10. The identification of USP8 mutations as contributors to the pathogenesis of ACTH (Montrer POMC Kits ELISA)-secreting pituitary adenomas represents an exciting advance in our understanding of Cushing's disease and its potential treatment into the of precision medicine.

Mouse (Murine) Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.

  2. in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.

  3. The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.

  4. a role for the USP8.STAM (Montrer STAM Kits ELISA) complex as a protective mechanism regulating early endosomal sorting of EGFR (Montrer EGFR Kits ELISA) between pathways destined for lysosomal degradation and recycling.

  5. USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.

  6. in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired

  7. Data indicate a novel mechanism where diacylglycerol kinase delta (Montrer DGKD Kits ELISA) and protein kinase (Montrer CDK7 Kits ELISA) Calpha (Montrer PRKACA Kits ELISA) modulate the levels of ubiquitinated epidermal growth factor (Montrer EGF Kits ELISA) receptors through Akt (Montrer AKT1 Kits ELISA) and ubiquitin-specific protease 8.

  8. deubiquitinating enzyme specifically expressed in testis, associates with the acrosome and centrosome in mouse germ cells

  9. Results indicate that Nrdp1 (Montrer RNF41 Kits ELISA) is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 (Montrer RNF41 Kits ELISA) activity by mediating its stabilization.

  10. We conclude that UBPY negatively regulates the rate of EGFR (Montrer EGFR Kits ELISA) down-regulation by deubiquitinating EGFR (Montrer EGFR Kits ELISA) on endosomes.

USP8 profil antigène

Antigen Summary

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

Gene names and symbols associated with USP8

  • ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109) anticorps
  • ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369) anticorps
  • ubiquitin specific peptidase 8 (USP8) anticorps
  • ubiquitin specific peptidase 8 (Usp8) anticorps
  • AI574262 anticorps
  • AW557536 anticorps
  • HumORF8 anticorps
  • mKIAA0055 anticorps
  • Ubpy anticorps

Protein level used designations for USP8

ubiquitin carboxyl-terminal hydrolase 8 , ubiquitin-specific-processing protease 8 , ubiquitin specific peptidase 8 , ubiquitin carboxyl-terminal hydrolase 8-like , deubiquitinating enzyme 8 , hUBPy , ubiquitin isopeptidase Y , ubiquitin specific protease 8 , ubiquitin thioesterase 8 , ubiquitin thiolesterase 8 , putative deubiquitinating enzyme

GENE ID SPECIES
9310109 Arabidopsis lyrata subsp. lyrata
10031598 Arthroderma gypseum CBS 118893
100408559 Callithrix jacchus
100437819 Pongo abelii
9101 Homo sapiens
296121 Rattus norvegicus
84092 Mus musculus
100157546 Sus scrofa
415451 Gallus gallus
100351436 Oryctolagus cuniculus
100720255 Cavia porcellus
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