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The protein encoded by ZMYM2 is a zinc finger protein that may act as a transcription factor. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Human Polyclonal ZMYM2 Primary Antibody pour EIA, WB - ABIN783367
Rosenfeld, Margalit: Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. dans Journal of biomolecular structure & dynamics 1994
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Human Polyclonal ZMYM2 Primary Antibody pour ICC, IF - ABIN4367041
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. dans Nature methods 2013
Multi-SUMO binding is mediated through multi-SIM (Montrer SIM2 Anticorps) modules, and the functional importance of these interactions is demonstrated for the transcriptional corepressor ZMYM2/ZNF198
downregulation of SUZ12 (Montrer SUZ12 Anticorps) and ZNF198 leads to epigenetic reprogramming of infected hepatocytes. Because both Plk1 (Montrer PLK1 Anticorps) and HOTAIR are elevated in many human cancers, we propose that their combined effects are involved in epigenetic reprogramming
B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11 (Montrer S100A10 Anticorps);q12)/ ZMYM2 (ZNF198)-FGFR1 (Montrer FGFR1 Anticorps)
We propose Plk1 (Montrer PLK1 Anticorps) activity down-regulates ZNF198 and SUZ12 (Montrer SUZ12 Anticorps), thereby enhancing both HBV replication and pX-mediated oncogenic transformation.
cell transformation mediated by ZNF198-FGFR1 (Montrer FGFR1 Anticorps) requires STAT5 (Montrer STAT5A Anticorps) activation
ZNF198/fibroblast growth factor receptor-1 (Montrer FGFR1 Anticorps) has signaling function comparable with interleukin-6 (Montrer IL6 Anticorps) cytokine receptors.
SUMO-1 (Montrer SUMO1 Anticorps), PML (Montrer PML Anticorps) and ZNF198 colocalize to punctate structures, shown by immunocytochemistry to be PML (Montrer PML Anticorps) bodies.
ZNF198-FGFR1 (Montrer FGFR1 Anticorps) activated both the AKT (Montrer AKT1 Anticorps) and mitogen activated protein kinase (Montrer MAPK1 Anticorps) (MAPK (Montrer MAPK1 Anticorps)) prosurvival signaling pathways, resulting in elevated phosphorylation of the AKT (Montrer AKT1 Anticorps) target FOXO3a (Montrer FOXO3 Anticorps) at T32 and BAD at S112, respectively.
HSPA1A (Montrer HSPA1A Anticorps) is an important regulator of the stability and function of ZNF198 and its oncogenic derivative, ZNF198-FGFR1 (Montrer FGFR1 Anticorps).
ZNF198, through its multiple protein-protein interaction interfaces, helps to maintain the intact LSD1 (Montrer KDM1A Anticorps)-CoREST (Montrer RCOR1 Anticorps)-HDAC1 (Montrer HDAC1 Anticorps) complex on specific, non-REST-responsive promoters and may also prevent SUMO-dependent dissociation of HDAC1 (Montrer HDAC1 Anticorps)
The study demonstrates frequent, constitutive activation of Notch1 (Montrer NOTCH1 Anticorps) and its downstream target genes in T-cell lymphomas that arose in a murine model of Zmym2-Fgfr1 (Montrer FGFR1 Anticorps) stem cell leukemia-lymphoma syndrome.
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene.
zinc finger, MYM-type 2
, zinc finger protein 198
, fused in myeloproliferative disorders protein
, rearranged in an atypical myeloproliferative disorder
, zinc finger MYM-type protein 2
, MYM-type zinc finger protein 2