alpha Ketoglutarate Dehydrogenase Protéines (alphaKGDHC)

alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. De plus, nous expédions alpha Ketoglutarate Dehydrogenase Anticorps (54) et alpha Ketoglutarate Dehydrogenase Kits (31) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
alphaKGDHC 4967 Q02218
alphaKGDHC 18293 Q60597
Rat alphaKGDHC alphaKGDHC 360975 Q5XI78
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Showing 6 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 67 Days
10.536,00 €
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 67 Days
10.536,00 €
Détails
HOST_HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 6 to 8 Days
748,00 €
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HOST_Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 6 to 8 Days
218,90 €
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Levure Mesocricetus auratus His tag   1 mg Connectez-vous pour afficher 58 to 70 Days
2.308,26 €
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HOST_Escherichia coli (E. coli) Humain T7 tag,His tag   100 μg Connectez-vous pour afficher 13 to 17 Days
624,76 €
Détails

alphaKGDHC Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour alpha Ketoglutarate Dehydrogenase (alphaKGDHC) partenaires d'interaction

Human alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS (Montrer LIAS Protéines)), which when mutated stabilize HIF1alpha (Montrer HIF1A Protéines) in a non-hydroxylated form.

  2. Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types

  3. Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.

  4. 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah

  5. Reduction in the E2k (Montrer DLST Protéines) subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Mouse (Murine) alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.

  2. Alpha-ketoglutarate dehydrogenase is a primary site of ROS (Montrer ROS1 Protéines) production in normally functioning mitochondria.

  3. In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.

Profil protéine alpha Ketoglutarate Dehydrogenase (alphaKGDHC)

Profil protéine

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with alphaKGDHC

  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH)
  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (Ogdh)
  • 2210403E04Rik Protéine
  • 2210412K19Rik Protéine
  • AA409584 Protéine
  • AKGDH Protéine
  • d1401 Protéine
  • E1k Protéine
  • mKIAA4192 Protéine
  • OGDC Protéine

Protein level used designations for alphaKGDHC

2-oxoglutarate dehydrogenase, mitochondrial , 2-oxoglutarate dehydrogenase complex component E1 , OGDC-E1 , oxoglutarate decarboxylase , oxoglutarate dehydrogenase (succinyl-transferring) , 2-oxoglutarate dehydrogenase E1 component, mitochondrial , alpha-ketoglutarate dehydrogenase , oxoglutarate dehydrogenase (lipoamide)

GENE ID SPECIES
426429 Gallus gallus
4967 Homo sapiens
475499 Canis lupus familiaris
534599 Bos taurus
18293 Mus musculus
360975 Rattus norvegicus
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