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alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. De plus, nous expédions alpha Ketoglutarate Dehydrogenase Anticorps (54) et alpha Ketoglutarate Dehydrogenase Kits (31) et beaucoup plus de produits pour cette protéine.
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oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS (Montrer LIAS Protéines)), which when mutated stabilize HIF1alpha (Montrer HIF1A Protéines) in a non-hydroxylated form.
Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types
Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.
2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah
Reduction in the E2k (Montrer DLST Protéines) subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.
pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2(-)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2 (Montrer GRX2 Protéines). Taken together, our results demonstrate GSH and GSSG modulate ROS (Montrer ROS1 Protéines) production by Ogdh through S-glutathionylation of different subunits
The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.
Alpha-ketoglutarate dehydrogenase is a primary site of ROS (Montrer ROS1 Protéines) production in normally functioning mitochondria.
In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
2-oxoglutarate dehydrogenase, mitochondrial
, 2-oxoglutarate dehydrogenase complex component E1
, oxoglutarate decarboxylase
, oxoglutarate dehydrogenase (succinyl-transferring)
, 2-oxoglutarate dehydrogenase E1 component, mitochondrial
, alpha-ketoglutarate dehydrogenase
, oxoglutarate dehydrogenase (lipoamide)