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STK3 encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. De plus, nous expédions STK3 Protéines (16) et beaucoup plus de produits pour cette protéine.
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Chicken Polyclonal STK3 Primary Antibody pour WB - ABIN2783468
Seidel, Schagdarsurengin, Blümke, Würl, Pfeifer, Hauptmann, Taubert, Dammann: Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. dans Molecular carcinogenesis 2007
Results show that STK3 is targeted by Casp6 (Montrer CASP6 Anticorps) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (Montrer CASP3 Anticorps)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.
using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (Montrer SAV1 Anticorps) refolded under acidic pH.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
These results suggest that AIF (Montrer AIFM1 Anticorps) downregulation is a common event in kidney tumor development. AIF (Montrer AIFM1 Anticorps) loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation
Hippo and Yap (Montrer YAP1 Anticorps) regulate cardiomyocyte death and regeneration.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
Results indicate that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo (MST1 (Montrer MST1 Anticorps)/2 protein kinases) signaling, providing a putative mechanism for pathway regulation.
RASSF5 (Montrer RASSF5 Anticorps) can act as an inhibitor or a potential positive regulator of Mst2, depending on whether it binds to Mst2 before or after activation-loop phosphorylation.
results of the present study revealed that, in addition to the phosphorylated YAP (Montrer YAP1 Anticorps)/TAZ (Montrer TAZ Anticorps), the Hippo pathway can suppress the Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) pathway directly through MST1 (Montrer MST1 Anticorps)/2
The ability of K-Ras to activate MST2 and MST2-dependent apoptosis is determined by the differential activation kinetics of mutant K-Ras and wild type K-Ras.
Studies indicate that Hippo (Hpo (Montrer GFER Anticorps); MST1 (Montrer MST1 Anticorps)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (Montrer NFKB1 Anticorps) pathway
the TLR-Mst1 (Montrer MST1 Anticorps)-Mst2-Rac (Montrer AKT1 Anticorps) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (Montrer STK4 Anticorps) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (Montrer MAP1LC3A Anticorps) by the STK3 (Montrer PKN1 Anticorps) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (Montrer MST1 Anticorps), as a critical regulator of caspase (Montrer CASP3 Anticorps)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (Montrer MST1 Anticorps)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (Montrer MST1 Anticorps)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
results showed that Mst1 (Montrer MST1 Anticorps)/Mst2 are required for proper cardiac lineage cell development and teratoma (Montrer DND1 Anticorps) formation.
these findings indicate that Mst1 (Montrer MST1 Anticorps)/2 are important for controlling Treg development and preventing autoimmunity in mice, but also shed new light on our understanding of Mst1 (Montrer MST1 Anticorps) deficiency-mediated human immunodeficiency syndrome.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)