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anti-Rat (Rattus) TNFSF9 Anticorps:
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Human Monoclonal TNFSF9 Primary Antibody pour FACS - ABIN2688965
Chu, DeBenedette, Stiernholm, Barber, Watts: Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells. dans Journal of immunology (Baltimore, Md. : 1950) 1997
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Mouse (Murine) Monoclonal TNFSF9 Primary Antibody pour BR, FACS - ABIN2688839
Akiba, Miyahira, Atsuta, Takeda, Nohara, Futagawa, Matsuda, Aoki, Yagita, Okumura: Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. dans The Journal of experimental medicine 2000
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Human Monoclonal TNFSF9 Primary Antibody pour ELISA, FACS - ABIN610414
Hutton, Christofori, Chi, Edman, Guest, Hanahan, Kelly: Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue. dans Molecular endocrinology (Baltimore, Md.) 1994
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Human Monoclonal TNFSF9 Primary Antibody pour ICC, FACS - ABIN1169256
Gullo, Koh, Pang, Ho, Tan, Schwarz: Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling. dans PLoS ONE 2010
Human Polyclonal TNFSF9 Primary Antibody pour CyTOF, FACS - ABIN4900479
Ek, Björck, Högerkorp, Nordenskjöld, Porwit-MacDonald, Borrebaeck: Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival. dans International journal of cancer 2006
the role of CD137 (Montrer TNFRSF9 Anticorps)-CRDI (cysteine rich domain I) in the binding of CD137 (Montrer TNFRSF9 Anticorps)-CD137L was further investigated.
Data indicate that anti-CD137 (Montrer TNFRSF9 Anticorps) agonists can function as inhibitors of CD137L signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.
Constitutive interaction between 4-1BB (Montrer TNFRSF9 Anticorps) and 4-1BBL on murine LPS (Montrer TLR4 Anticorps)-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS (Montrer PTK6 Anticorps)-1 but not 19H3 antibody.
4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues
These results demonstrate that 4-1BBL-engineered DCs can improve CIKs (Montrer TRAF3IP2 Anticorps) cytotoxicity against prostate cancer cells.
these observations suggest that inhibition of the TLR/4 (Montrer TLR4 Anticorps)-1BBL complex formation may be highly efficient in protecting against continued inflammation
4-1BB (Montrer TNFRSF9 Anticorps) mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.
CD137 (Montrer TNFRSF9 Anticorps)-CD137L interactions mediated via regulation of CyPA (Montrer PPIA Anticorps) contribute to the progression of atherosclerosis.
Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions.
monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB (Montrer TNFRSF9 Anticorps), and in conjunction with this pathway, maintain their numbers at baseline.
blocking of both OX-40L (Montrer TNFSF4 Anticorps) and 4-1BBL reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.
CD137L is overexpressed in non-small cell lung cancer specimens and positive expression of CD137L was associated with better overall survival.
In vitro immunotherapy is described for anti-prostate cancer effects of cytotoxic T lymphocytes induction by recombinant adenovirus mediated PSMA/4 (Montrer PSMA4 Anticorps)-1BBL dendritic cells.
vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3 (Montrer CD3 Anticorps)+CD8 (Montrer CD8A Anticorps)+ TIL (Montrer TLR1 Anticorps) and NK cells, decreased the number of FOXP3 (Montrer FOXP3 Anticorps) cells and inhibited the development of DMH (Montrer DST Anticorps)-induced colorectal cancer
Elevated plasma levels and monocyte-associated expression of CD137 (Montrer TNFRSF9 Anticorps) ligand in patients with acute atherothrombotic stroke
Hence, the targeted combination of IL-15 (Montrer IL15 Anticorps) and 4-BBL (Montrer TP53 Anticorps) in the form of a trifunctional antibody-fusion protein is a promising new approach for cancer immunotherapy.
TIRAP (Montrer TIRAP Anticorps) and IRAK2 (Montrer IRAK2 Anticorps) are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4 (Montrer TLR4 Anticorps)-1BBL complex.
this is the first study to indicate that this member of the TNF (Montrer TNF Anticorps) superfamily, CD137 (Montrer TNFRSF9 Anticorps), is modulated by SAHA treatment in breast
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
, tumor necrosis factor (ligand) superfamily, member 9
, 4-1BB ligand
, tumor necrosis factor ligand superfamily member 9
, homolog of mouse 4-1BB-L
, receptor 4-1BB ligand