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anti-Human HCK Anticorps:
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Dog (Canine) Monoclonal HCK Primary Antibody pour IF, IP - ABIN967878
Baumgartner, Angelisová, Setterblad, Mooney, Werling, Horejsí, Langsley: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. dans Blood 2003
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Dog (Canine) Monoclonal HCK Primary Antibody pour IF, IP - ABIN967877
Briggs, Smithgall: SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts. dans The Journal of biological chemistry 1999
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Human Monoclonal HCK Primary Antibody pour IHC, ELISA - ABIN969187
Schnoor: What I learned in Europe.... dans Environmental science & technology 2007
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Human Monoclonal HCK Primary Antibody pour PLA, ELISA - ABIN561237
Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. dans Molecular & cellular proteomics : MCP 2013
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck-dependent activation of PKCdelta (Montrer PKCd Anticorps), which stimulates PKCgamma (Montrer PRKCG Anticorps), resulting in translocation of phosphorylated p47(phox).
HCK represents a novel target for therapeutic development in MYD88 (Montrer MYD88 Anticorps)-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88 (Montrer MYD88 Anticorps).
High HCK levels correlate with reduced survival of colorectal cancer patients and is associated with activated macrophages gene signature.
three-dimensional (3D) QSAR pharmacophore models were generated for Hck based on experimentally known inhibitors. A best pharmacophore model, Hypo1, was developed with high correlation coefficient (0.975), Low RMS deviation (0.60) and large cost difference (49.31), containing three ring aromatic and one hydrophobic aliphatic feature
we provide evidence for involvement of HCK and FGR (Montrer FGR Anticorps) in FCRL4 (Montrer FCRL4 Anticorps)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (Montrer FCRL4 Anticorps) molecule.
Interaction with the Src (Montrer SRC Anticorps) homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity.
Data indicate that combined treatment using SFK (LYN (Montrer LYN Anticorps), HCK, or FGR (Montrer FGR Anticorps)) and c-KIT (Montrer KIT Anticorps) inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (Montrer TP53 Anticorps) activity and enhancing targeting of acute myeloid leukemia (Montrer BCL11A Anticorps) (AML (Montrer RUNX1 Anticorps)) stem cells.
The SRC (Montrer SRC Anticorps) family tyrosine kinase (Montrer TXK Anticorps) HCK and the ETS (Montrer ETS1 Anticorps) family transcription factors SPIB (Montrer SPIB Anticorps) and EHF (Montrer EHF Anticorps) regulate transcytosis across a human follicle-associated epithelium model.
This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.
the Hck, Fgr (Montrer FGR Anticorps) and Lyn (Montrer LYN Anticorps) kinases are also necessary for amastigote uptake by macrophages. Src (Montrer SRC Anticorps)-mediated Arg activation is required for efficient uptake.
Hematopoietic Hck promotes tumorigenesis.
Data suggest that Hck is a key mediator of renal fibrosis
Data indicate that Src (Montrer SRC Anticorps)-Family Kinases Hck and Fgr (Montrer FGR Anticorps) regulate cytokine secretion by macrophages.
Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.
The Src (Montrer SRC Anticorps) family kinases Hck, Fgr (Montrer FGR Anticorps), and Lyn (Montrer LYN Anticorps) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
tyrosine phosphorylation of WASP by Hck is required for proper macrophage functions
Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.
Despite possessing enhanced killing, alveolar macrophage Hck/Fgr (Montrer FGR Anticorps)/Lyn (Montrer LYN Anticorps)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Taken together, PKR (Montrer EIF2AK2 Anticorps) and Hck were critical for DON-induced ribosomal recruitment of p38 (Montrer CRK Anticorps), its subsequent phosphorylation, and, ultimately, p38 (Montrer CRK Anticorps)-driven proinflammatory cytokine expression.
A truncated, mRNA-encoded src-related tyrosine kinase (Montrer FRK Anticorps) HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.
the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.
hemopoietic cell kinase
, non-receptor protein tyrosine kinase laloo
, tyrosine-protein kinase HCK-like
, hematopoietic cell kinase
, tyrosine-protein kinase HCK
, B cell/myeloid kinase
, B-cell/myeloid kinase
, hemopoietic cell tyrosine kinase