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anti-Human TMEM173 Anticorps:
anti-Mouse (Murine) TMEM173 Anticorps:
anti-Rat (Rattus) TMEM173 Anticorps:
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Human Polyclonal TMEM173 Primary Antibody pour ICC, IF - ABIN4356573
Furr, Chauhan, Moerdyk-Schauwecker, Marriott: A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells. dans Journal of neuroinflammation 2011
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Human Polyclonal TMEM173 Primary Antibody pour ICC, IF - ABIN4356571
Heiber, Barber: Evaluation of innate immune signaling pathways in transformed cells. dans Methods in molecular biology (Clifton, N.J.) 2011
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Human Polyclonal TMEM173 Primary Antibody pour WB - ABIN2783202
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... dans Genome research 2004
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Human Monoclonal TMEM173 Primary Antibody pour CyTOF, FACS - ABIN4899624
Schoggins, MacDuff, Imanaka, Gainey, Shrestha, Eitson, Mar, Richardson, Ratushny, Litvak, Dabelic, Manicassamy, Aitchison, Aderem, Elliott, García-Sastre, Racaniello, Snijder, Yokoyama, Diamond et al.: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. ... dans Nature 2014
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study identifies the AIM2 (Montrer AIM2 Anticorps) inflammasome and cGAS/IFI16 (Montrer IFI16 Anticorps)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
NEMO (Montrer IKBKG Anticorps) was critically involved in the cGAS-STING pathway.
Studied association of genetic variants of the MAVS, MITA and MFN2 genes with leprosy in Han Chinese from Southwest China; found no association between the variants and susceptibility to leprosy.
both IL-6 (Montrer IL6 Anticorps) and RIG-I (Montrer DDX58 Anticorps) are downstream molecules of STING along the DNA sensor pathway.
We discuss three newly described monogenic autoinflammatory diseases [deficiency of adenosine deaminase 2 (Montrer CECR1 Anticorps) (DADA2), a subtype of macrophage activation syndrome (MAS (Montrer MAS1 Anticorps)), and stimulator of interferon (Montrer IFNA Anticorps) genes (STING)-associated vasculopathy with onset in infancy (SAVI)], discuss the possibilities of somatic mosaicism and digenic inheritance, and give an update on new concepts in pathways involved in familial Mediterranean fever (Montrer MEFV Anticorps)
Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon (Montrer IFNA Anticorps) signaling
a critical role of p38 (Montrer CRK Anticorps)-mediated USP21 (Montrer USP21 Anticorps) phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (Montrer CRK Anticorps)-USP21 (Montrer USP21 Anticorps) axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.
Human herpesvirus 1 ICP27 interacted with TBK1 (Montrer TBK1 Anticorps) and STING in a manner that was dependent on TBK1 (Montrer TBK1 Anticorps) activity and the RGG motif in ICP27 and inhibited type I IFN induction through the cGAS-STING-TBK1 (Montrer TBK1 Anticorps) pathway in human macrophages.
Multivariate analysis supported TMEM173 as an independent prognostic factor.
Data show that stimulator of interferon (Montrer IFNA Anticorps) genes (STING)-associated vasculopathy with onset in infancy (SAVI)-associated STING N153S mutation triggers IRF3 (Montrer IRF3 Anticorps)-independent immune cell dysregulation and lung disease in mice.
These results highlight the crucial role of MFN1 (Montrer MFN1 Anticorps) in maintaining the competency of the STING pathway.
to contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin (Montrer BST2 Anticorps), a viral restriction factor
found that CCCP impairs the interaction between STING and TBK1 (Montrer TBK1 Anticorps) and concomitantly triggers mitochondria fission.
Yersinia YopJ negatively regulates IRF3 (Montrer IRF3 Anticorps)-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
demonstrate that in colon tumor model, therapeutic anti-CD47 (Montrer CD47 Anticorps) preferentially relies on STING-mediated DNA sensing in dendritic cells
STING is a central mediator of interferon (Montrer IFNA Anticorps) regulated inflammasome activation in Chlamydia trachomatis infection.
this study shows that immune rejection of prostate cancer cells relies on Mus81 (Montrer MUS81 Anticorps) and STING
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
transmembrane protein 173
, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
, endoplasmic reticulum IFN stimulator
, endoplasmic reticulum interferon stimulator
, mediator of IRF3 activation
, mitochondrial mediator of IRF3 activation
, stimulator of interferon genes protein
, Stimulator of interferon genes protein
, mitochondrial transmembrane protein 173