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CD63 anticorps (Biotin)

CD63 Reactivité: Humain FACS, IHC (p), IP, ICC Hôte: Souris Monoclonal MEM-259 Biotin
N° du produit ABIN1027697
  • Antigène Voir toutes CD63 Anticorps
    CD63
    Reactivité
    • 134
    • 52
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 82
    • 63
    • 7
    • 3
    Souris
    Clonalité
    • 106
    • 47
    • 2
    Monoclonal
    Conjugué
    • 74
    • 12
    • 11
    • 9
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD63 est conjugé à/à la Biotin
    Application
    • 97
    • 70
    • 51
    • 46
    • 37
    • 28
    • 26
    • 20
    • 18
    • 17
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificité
    The antibody MEM-259 reacts with an extracellular/luminal epitope of CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
    Immunogène
    HPB-ALL T cell line
    Clone
    MEM-259
    Isotype
    IgG1
    Top Product
    Discover our top product CD63 Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-3 μg/mL, positive material: activated platelets, neutrophils and basophils.
    Commentaires

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Luddi, Zarovni, Maltinti, Governini, Leo, Cappelli, Quintero, Paccagnini, Loria, Piomboni: "Clues to Non-Invasive Implantation Window Monitoring: Isolation and Characterisation of Endometrial Exosomes." dans: Cells, Vol. 8, Issue 8, (2020) (PubMed).

    Heneberg, Riegerová, Kučera: "Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0142953, (2015) (PubMed).

    Cerny, Feng, Yu, Miyake, Borgonovo, Klumperman, Meldolesi, McNeil, Kirchhausen: "The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing." dans: EMBO reports, Vol. 5, Issue 9, pp. 883-8, (2004) (PubMed).

  • Antigène
    CD63
    Autre désignation
    CD63 (CD63 Produits)
    Synonymes
    anticorps C75951, anticorps ME491, anticorps Tspan30, anticorps LAMP-3, anticorps MLA1, anticorps OMA81H, anticorps TSPAN30, anticorps TSP29FA, anticorps CD63 antigen, anticorps CD63 molecule, anticorps Cd63 molecule, anticorps Cd63, anticorps CD63
    Sujet
    CD63 Molecule,CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.,OMA81H, Granulophysin, Tetraspanin-30, Tspan-30, MLA1, ME491, LAMP-3, OMA81H, TSPAN30
    ID gène
    967
    UniProt
    P08962
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