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anti-matrix metalloprotease 1 (MMP1) anticorps

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Antigène: Matrix metalloprotease 1 (MMP1)
Clonalité: Polyclonal
Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reactivité: Human
Hôte: Rabbit
1 référence disponible 1 référence disponible
Quantité: 1ml (100ug/ml approximately) (Alternatives)
Prix: 466,30 €   (Plus frais de livraison et TVA)
Numéro du produit: ABIN103982
Disponibilité: Envoi sous 5 jours ouvrables
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Description du produit  » anti-matrix metalloprotease 1 (MMP1) anticorps

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Antigène Matrix metalloprotease 1 (MMP1)
Immunogène A synthetic peptide from the middle region of the human MMP-1.
Reactivité Human
Clonalité Polyclonal
Format Ig-fraction, Purified
Hôte Rabbit
Specificité This antibody reacts with a 52 kD protein (unglycosylated) and 57 kD (glycosylated) species of pro form of MMP-1 as well as 42 kD (unglycosylated) and 47 kD (glycosylated) active form of MMP-1. Matrix metalloproteinase (MMPs) are a family of closely related zinc-containing proteolytic enzymes, capable of degrading connective tissue components. MMP-1 appears to be associated with facilitating the tumor spread and invasion of esophageal and colorectal cancers and is associated with poor prognosis. Interstitial collagenase (MMP-1), 73 kD gelatinase A/type IV collagenase (MMP-2) and 92 kD gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix and may initiate and promote angiogenesis.

Applications  » anti-matrix metalloprotease 1 (MMP1) anticorps

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Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Indications d'application Titer/Working Dilution: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Placenta. Cellular localization: Cytoplasmic
Concentration 100ug/ml approximately
Buffer Purified immunoglobulin fraction of rabbit antiserum against MMP-1 containing sodium azide as preservative.
Stock Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.
Domaine de recherche Matrice extracellulaire
Restrictions For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union

Références  » anti-matrix metalloprotease 1 (MMP1) anticorps

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Références Windsor, Birkedal-Hansen, Birkedal-Hansen et al.: "An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase." In: Biochemistry , Vol. 30, Issue 3, pp. 641-7, 1991 (PubMed)