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PDCD4 anticorps (Internal Region, pSer457) (Biotin)

PDCD4 Reactivité: Humain, Souris, Rat, Xenopus laevis WB, ELISA, IHC Hôte: Souris Monoclonal 9G6 Biotin
N° du produit ABIN1043755
  • Antigène Voir toutes PDCD4 Anticorps
    PDCD4 (Programmed Cell Death 4 (PDCD4))
    Épitope
    • 15
    • 14
    • 13
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region, pSer457
    Reactivité
    • 103
    • 69
    • 59
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Humain, Souris, Rat, Xenopus laevis
    Hôte
    • 96
    • 5
    • 2
    • 1
    Souris
    Clonalité
    • 92
    • 12
    Monoclonal
    Conjugué
    • 59
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PDCD4 est conjugé à/à la Biotin
    Application
    • 75
    • 43
    • 35
    • 16
    • 14
    • 14
    • 13
    • 9
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    Anti-Pdcd4 pS457 (MOUSE) Monoclonal Antibody Biotin Conjugated was purified from concentrated tissue culture supernate by Protein A chromatography. This antibody is specific for human Pdcd4 protein phosphorylated at Ser457. A BLAST analysis was used to suggest cross-reactivity with Pdcd4 from human, mouse, rat and Xenopus based on 100% homology with the immunizing sequence. Cross-reactivity with Pdcd4 from other sources has not been determined.
    Attributs du produit
    Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.
    Immunogène
    This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein.
    Immunogen Type: Peptide
    Clone
    9G6
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product PDCD4 Anticorps primaire
  • Indications d'application
    Anti-Pdcd4 pS457 (MOUSE) Monoclonal Antibody Biotin Conjugated is suitable for ELISA, immunohistochemistry and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 62 kDa in size corresponding to phosphorylated Pdcd4 protein by western blotting in the appropriate cell lysate or extract. This phospho-specific monoclonal antibody reacts with human Pdcd4 pS457 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.
    Commentaires

    Gene Name: PDCD4

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL
    Concentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Date de péremption
    12 months
  • Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: "Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion." dans: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18515-24, (2009) (PubMed).

    Jansen, Camalier, Colburn: "Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis." dans: Cancer research, Vol. 65, Issue 14, pp. 6034-41, (2005) (PubMed).

  • Antigène
    PDCD4 (Programmed Cell Death 4 (PDCD4))
    Autre désignation
    Pdcd4 (PDCD4 Produits)
    Synonymes
    anticorps H731, anticorps D19Ucla1, anticorps Ma3, anticorps Tis, anticorps Dug, anticorps cb45, anticorps pdcd4, anticorps sb:cb45, anticorps wu:fc84b08, anticorps h731, anticorps MGC69337, anticorps PDCD4, anticorps wu:fa55g03, anticorps wu:fb08a11, anticorps wu:fe01a02, anticorps zgc:66311, anticorps programmed cell death 4, anticorps programmed cell death 4b, anticorps programmed cell death 4 L homeolog, anticorps programmed cell death 4 (neoplastic transformation inhibitor), anticorps programmed cell death 4a, anticorps PDCD4, anticorps Pdcd4, anticorps pdcd4b, anticorps pdcd4.L, anticorps pdcd4, anticorps pdcd4a
    Sujet
    Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.
    Synonyms: Death up-regulated gene protein antibody, Dug antibody, H731 antibody, Ma3 antibody, Neoplastic transformation inhibitor antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731 antibody
    ID gène
    27250, 21735596
    UniProt
    Q53EL6
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