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IDO1 anticorps

IDO1 Reactivité: Souris WB, ELISA, IHC, FACS Hôte: Souris Monoclonal 2E2-6 unconjugated
N° du produit ABIN1043820
  • Antigène Voir toutes IDO1 Anticorps
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Reactivité
    • 62
    • 31
    • 16
    • 8
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 57
    • 11
    • 1
    • 1
    Souris
    Clonalité
    • 56
    • 15
    Monoclonal
    Conjugué
    • 48
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IDO1 est non-conjugé
    Application
    • 63
    • 32
    • 23
    • 19
    • 16
    • 15
    • 14
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Specificité
    Anti-IDO1 antibody was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above. IDO1 antibody is specific for mouse IDO1 protein. Mouse IDO1 does not react with human tissues. Cross-reactivity with IDO1 from other sources has not been determined.
    Attributs du produit
    Anti-IDO-1 antibody recognizes indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
    Stérilité
    Sterile filtered
    Immunogène
    IDO1 antibody was produced in mouse by repeated immunizations with mouse recombinant IDO1 protein followed by hybridoma development.
    Immunogen Type: RecombinantProtein
    Clone
    2E2-6
    Isotype
    IgG1
  • Indications d'application
    Anti-IDO1 antibody has been tested for use in ELISA, Western Blot, IF, IHC, and Flow Cytometry. Specific conditions for reactivity should be optimized by the end user.
    Commentaires

    Gene Name: Ido1

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.95 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Date de péremption
    12 months
  • Mellor, Munn: "IDO expression by dendritic cells: tolerance and tryptophan catabolism." dans: Nature reviews. Immunology, Vol. 4, Issue 10, pp. 762-74, (2004) (PubMed).

  • Antigène
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Autre désignation
    IDO1 (IDO1 Produits)
    Synonymes
    anticorps INDO, anticorps ido, anticorps indo, anticorps IDO, anticorps cd107b, anticorps IDO1, anticorps IDO-1, anticorps Ido, anticorps Indo, anticorps indoleamine 2,3-dioxygenase 1, anticorps indoleamine 2,3-dioxygenase 1 L homeolog, anticorps indoleamine 2,3-dioxygenase 1-like, anticorps IDO1, anticorps ido1.L, anticorps ido1, anticorps Ido1, anticorps LOC100050681
    Sujet
    Anti-IDO-1 antibody recognizes indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
    Synonyms: Ido, Indo, Indoleamine 2,3-dioxygenase 1, Indoleamine-pyrrole 2,3-dioxygenase, Ido 1, Ido-1, IDO1 antibody, anti-IDO1 antibody
    ID gène
    15930
    NCBI Accession
    NP_032350
    UniProt
    P28776
    Pathways
    Activated T Cell Proliferation
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