ING4 anticorps (Isoform 1)

N° du produit ABIN105223

Détail du produit anti-ING4 anticorps

Antigène: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Épitope: AA 164-175, Isoform 1

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ING4 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 164-175 of Human p29 ING4 protein (Inhibitor of growth family, member 4). This sequence only shows homology to for ING4.

Isotype: IgG

Information d'application

Indications d'application: This affinity-purified antibody has been tested for use in ELISA against the immunizing peptide.  Specific conditions for western blotting reactivity should be optimized by the end user.  Expect a band at approximately 29 kDa in size corresponding to ING4 isoform 1 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.28 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ING4 (ABIN105223)

Colla, Tagliaferri, Morandi, Lunghi, Donofrio, Martorana, Mancini, Lazzaretti, Mazzera, Ravanetti, Bonomini, Ferrari, Miranda, Ladetto, Neri, Neri, Greco, Mangoni, Bonati, Rizzoli, Giuliani et al.: "The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha ..." dans: Blood, Vol. 110, Issue 13, pp. 4464-75, (2007) (PubMed).

Unoki, Shen, Zheng, Harris: "Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility." dans: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34677-86, (2006) (PubMed).

Détails sur ING4

Antigène: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Autre désignation: p29 ING4 (ING4 Produits)

Synonymes: anticorps wu:fb11d09, anticorps wu:fb50e02, anticorps zgc:110619, anticorps ING4, anticorps my036, anticorps p29ING4, anticorps D6Wsu147e, anticorps D6Xrf92, anticorps inhibitor of growth family, member 4, anticorps inhibitor of growth family member 4, anticorps ing4, anticorps ING4, anticorps Ing4

Sujet: P29 ING4 is a tumor suppressor protein similar to ING1 that  may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA.  p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) that encodes the longest isoform.
Synonyms: NG-4 antibody, ING1 like protein antibody, Inhibitor of growth family member 4 antibody, Inhibitor of growth family member 4 long isoform antibody, Inhibitor of growth protein 4 antibody, MGC12557 antibody

ID gène: 51147

UniProt: Q9UNL4