HAS2 anticorps (AA 67-170)

N° du produit ABIN1098124

Détail du produit anti-HAS2 anticorps

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Épitope: AA 67-170

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HAS2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: purified

Immunogène: Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. coli.

Clone: 4-00E-07

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-HAS2 (ABIN1098124)

Okuda, Kobayashi, Xia, Watabe, Pai, Hirota, Xing, Liu, Pandey, Fukuda, Modur, Ghosh, Wilber, Watabe: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." dans: Cancer research, Vol. 72, Issue 2, pp. 537-47, (2012) (PubMed).

Jokela, Makkonen, Oikari, Kärnä, Koli, Hart, Tammi, Carlberg, Tammi: "Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1." dans: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33632-40, (2011) (PubMed).

Détails sur HAS2

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Autre désignation: HAS2 (HAS2 Produits)

Synonymes: anticorps DG42, anticorps XHas2, anticorps Has2, anticorps hyaluronan synthase 2, anticorps hyaluronan synthase 2 S homeolog, anticorps has2, anticorps HAS2, anticorps Has2, anticorps SHAS2, anticorps has2.S

Sujet: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Poids moléculaire: 63.5 kDa

ID gène: 3037

HGNC: 3037

Pathways: Glycosaminoglycan Metabolic Process