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CD45 anticorps

PTPRC Reactivité: Humain FACS, IF, IHC (p), IHC (fro) Hôte: Souris Monoclonal MT4 unconjugated
N° du produit ABIN1106409
  • Antigène Voir toutes CD45 (PTPRC) Anticorps
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    Reactivité
    • 419
    • 252
    • 88
    • 29
    • 20
    • 16
    • 15
    • 10
    • 7
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    • 6
    • 6
    • 4
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    • 3
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    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 305
    • 201
    • 148
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 513
    • 137
    • 1
    Monoclonal
    Conjugué
    • 185
    • 62
    • 54
    • 52
    • 39
    • 17
    • 15
    • 12
    • 12
    • 12
    • 10
    • 10
    • 10
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    • 5
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    • 4
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    • 4
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    • 4
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    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp CD45 est non-conjugé
    Application
    • 534
    • 213
    • 160
    • 137
    • 135
    • 80
    • 70
    • 60
    • 47
    • 27
    • 19
    • 17
    • 15
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    • 2
    • 2
    • 1
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    • 1
    • 1
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    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    Clone MT4 reacts with the 190, 205 and 220 kDa isoforms of the cell-surface antigen CD45RB. Variations in CD45RB expression can discriminate between Th1 and Th 2 cells, i.e. CD45RBbright and CD45RB-dim respectively [8]. CD45RB bright expression on T cells correlates with higher proliferation and IFN-g production in comparison to CD45RB dim expression. 90 % of lymphocytes are CD45RB positive. Other isoforms can be detected using anti-CD45RA (clone MB1, cat.no. AM39020), or anti-CD45RC (clone MT2, cat.no. AM39022).
    Purification
    Affinity chromatography
    Clone
    MT4
    Isotype
    IgG1
    Top Product
    Discover our top product PTPRC Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
  • Antigène
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    Autre désignation
    CD45 / LCA (PTPRC Produits)
    Synonymes
    anticorps PTPRC, anticorps si:dkeyp-47c5.1, anticorps B220, anticorps CD45, anticorps CD45R, anticorps GP180, anticorps L-CA, anticorps LCA, anticorps LY5, anticorps T200, anticorps Cd45, anticorps Ly-5, anticorps Lyt-4, anticorps loc, anticorps Lca, anticorps RT7, anticorps cd45, anticorps protein tyrosine phosphatase, receptor type C, anticorps protein tyrosine phosphatase, receptor type, C, anticorps receptor-type tyrosine-protein phosphatase C, anticorps PTPRC, anticorps ptprc, anticorps LOC100074271, anticorps Ptprc
    Sujet
    The CD45 Molecule is also known as the Leukocyte Common Antigen (LCA) or T200 antigen, and is comprised of different glycoproteins ranging from 180-240 kD [1,2]. CD45 is a family of transmembrane protein tyrosine phosphatases critically involved in the regulation of lymphocyte activation signals. Expression of CD45 is found on all hemopoietic cells, e.g. granulocytes, monocytes, macrophages and lymphocytes, except mature erythroid cells. In humans, there is heterogeneous expression of CD45 isoforms (RA, RB, RO, RC) on lymphocyte subpopulations. Detection of the different isoforms can distinguish, for example, between naive T cells and memory T cells, which is of interest in patients with immunodeficiency and autoimmune diseases.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
    ID gène
    5788
    NCBI Accession
    NP_002829
    UniProt
    P08575
    Pathways
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
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