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Cyclin D1 anticorps

CCND1 Reactivité: Humain, Rat, Souris WB, IF, IHC (p), IHC (fro) Hôte: Souris Monoclonal CY-D1 unconjugated
N° du produit ABIN1106872
  • Antigène Voir toutes Cyclin D1 (CCND1) Anticorps
    Cyclin D1 (CCND1)
    Reactivité
    • 246
    • 131
    • 125
    • 38
    • 19
    • 19
    • 17
    • 10
    • 9
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 211
    • 59
    • 1
    Souris
    Clonalité
    • 199
    • 70
    Monoclonal
    Conjugué
    • 122
    • 29
    • 21
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cyclin D1 est non-conjugé
    Application
    • 207
    • 90
    • 73
    • 68
    • 42
    • 34
    • 27
    • 27
    • 25
    • 22
    • 20
    • 14
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This antibody reacts to Cyclin D1.
    Purification
    Affinity chromatography
    Immunogène
    Recombinant human cyclin D1 protein
    Clone
    CY-D1
    Isotype
    IgG2a
    Top Product
    Discover our top product CCND1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore with 1.2 % sodium acetate or neutral PBS
    Concentration
    0,1 mg/mL
    Buffer
    1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    Cyclin D1 (CCND1)
    Autre désignation
    Cyclin D1 (CCND1 Produits)
    Synonymes
    anticorps BCL1, anticorps D11S287E, anticorps PRAD1, anticorps U21B31, anticorps AI327039, anticorps CycD1, anticorps Cyl-1, anticorps bcl-1, anticorps cD1, anticorps cb161, anticorps cycd1, anticorps etID37810.7, anticorps fb52e01, anticorps fc45c08, anticorps fc83a12, anticorps id:ibd1198, anticorps wu:fb52e01, anticorps wu:fc45c08, anticorps wu:fc83a12, anticorps ccnd1b, anticorps prad1, anticorps ccnd1, anticorps ccnd1a, anticorps bcl1, anticorps d11s287e, anticorps u21b31, anticorps CCND1, anticorps cyclin D1, anticorps cyclin D1 S homeolog, anticorps cyclin D1 L homeolog, anticorps CCND1, anticorps Ccnd1, anticorps ccnd1, anticorps ccnd1.S, anticorps ccnd1.L
    Sujet
    D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. CyclinD1(CCND1), also known as BCL1. Expression of cyclin D1, but not of cyclins A and E, was induced by transfection of the RB gene into RB-deficient tumor cells. cyclin D1 gene can function as an oncogene. Cyclin D1 expression is regulated by the retinoblastoma protein. The protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al. (2003) found that prolactin induced IGF2 mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.Synonyms: BCL-1 oncogene, BCL1, CCND1, Cyclin-D1, G1/S-specific cyclin-D1, PRAD-1 oncogene, PRAD1
    ID gène
    595
    NCBI Accession
    NP_444284
    UniProt
    P24385
    Pathways
    Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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