Desmoplakin anticorps (Internal Region)

N° du produit ABIN1106985

Détail du produit anti-Desmoplakin anticorps

Antigène: Desmoplakin (DSP)

Épitope: AA 1672-1684, Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Desmoplakin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: C-QESVKQAHLR NEH Remarks: Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Marmoset (100%), Monkey (92%), Mouse (92%), Rat (92%), Hamster (92%), Elephant (92%), Dog (92%), Horse (92%), Rabbit (92%), Opossum (92%), Platypus (92%), Panda (85%), Bat (85%), Turkey (85%), Chicken (85%).

Specificité: This antibody is expected to recognize reported isoform I (NP_004406.2) only.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide from the internal region of Human DSP / Desmoplakin (NP_004406.2). Genename: DSP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Desmoplakin

Antigène: Desmoplakin (DSP)

Autre désignation: Desmoplakin (DSP Produits)

Synonymes: anticorps DP, anticorps DPI, anticorps DPII, anticorps DSP, anticorps dpi, anticorps dpii, anticorps 2300002E22Rik, anticorps 5730453H04Rik, anticorps AA407887, anticorps AA407888, anticorps AW109828, anticorps im:6911953, anticorps sb:cb570, anticorps wu:fc17a08, anticorps wu:fk73d01, anticorps desmoplakin, anticorps Desmoplakin, anticorps ORF113, anticorps desmoplakin a, anticorps ORF112 DESMOPLAKIN, anticorps orf102, anticorps orf91; similar to Cydia pomonella granulovirus orf112, anticorps ORF62, anticorps ORF-66, anticorps ORF57, anticorps agip105, anticorps similar to XcORF133; similar to HaGV desmoplakin, anticorps desmoplakin L homeolog, anticorps ORF96, anticorps DSP, anticorps PhopGV104, anticorps ORF-59 desmoplakin, anticorps desmop, anticorps Dsp, anticorps dsp, anticorps desmoplakin, anticorps dspa, anticorps orf112 desmoplakin, anticorps ClgVgp102, anticorps COGV_gp091, anticorps APNV_p087, anticorps CBNV_gp066, anticorps EONV_gp057, anticorps OLNV_gp066, anticorps AgipMNPV_gp105, anticorps HaMNV_gp106, anticorps EupsNPV_gp065, anticorps PsunGV_gp139, anticorps dsp.L, anticorps ClanGV_gp096

Sujet: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP

ID gène: 1832

NCBI Accession: NP_001008844

Pathways: Cell-Cell Junction Organization