MARCO anticorps (AA 420-431)

N° du produit ABIN1108157

Détail du produit anti-MARCO anticorps

Antigène: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Épitope: AA 420-431

Reactivité: Humain, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MARCO est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificité: This antibody binds specifically to MARCO (recognizes domain V between residues 420 and 431), and has been shown to partially block ligand binding.

Aucune reactivité croisée: Poulet

Réactivité croisée (Details): Species reactivity (tested):Human, Bovine.

Purification: Protein G Chromatography

Immunogène: Human alveolar macrophages

Clone: PLK-1

Isotype: IgG3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur MARCO

Antigène: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Autre désignation: MARCO (MARCO Produits)

Synonymes: anticorps AI323439, anticorps Ly112, anticorps Scara2, anticorps SCARA2, anticorps macrophage receptor with collagenous structure, anticorps MARCO, anticorps Marco

Sujet: The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens.Synonyms: Scavenger Receptor, macrophage receptor with collagenous structure

ID gène: 8685

NCBI Accession: NP_006761

UniProt: Q9UEW3

Pathways: Activation of Innate immune Response