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Vitronectin anticorps

VTN Reactivité: Humain WB, IP, IF, EIA Hôte: Souris Monoclonal BV1 unconjugated
N° du produit ABIN1109496
  • Antigène Voir toutes Vitronectin (VTN) Anticorps
    Vitronectin (VTN)
    Reactivité
    • 95
    • 32
    • 32
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 92
    • 19
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 86
    • 29
    Monoclonal
    Conjugué
    • 59
    • 12
    • 8
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Vitronectin est non-conjugé
    Application
    • 70
    • 49
    • 39
    • 22
    • 14
    • 13
    • 12
    • 11
    • 9
    • 9
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    Monoclonal antibody BV1 recognizes human vitronectin. Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. It binds to soluble vitronectin as well as to membrane bound vitronectin.
    Réactivité croisée (Details)
    Species reactivity (tested):Human
    Purification
    Protein G
    Clone
    BV1
    Isotype
    IgG1
    Top Product
    Discover our top product VTN Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2 - 8 °C.
  • Antigène
    Vitronectin (VTN)
    Autre désignation
    Vitronectin (VTN Produits)
    Synonymes
    anticorps VTN, anticorps DKFZp470F0511, anticorps LOC100228142, anticorps vtn, anticorps zgc:112277, anticorps V75, anticorps VN, anticorps VNT, anticorps AI256434, anticorps Vn, anticorps Aa1018, anticorps vitronectin, anticorps vitronectin a, anticorps vitronectin b, anticorps vitronectin L homeolog, anticorps VTN, anticorps vtn, anticorps vtna, anticorps vtnb, anticorps CpipJ_CPIJ016691, anticorps vtn.L, anticorps Vtn
    Sujet
    Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. About one third of the protein molecular mass is composed of carbohydrates. Vitronectin is found in blood plasma and the extracellular matrix. Vitronectin is a multifunctional protein, since it promotes attachment and spreading of animal cells in vitro, it inhibits cytolysis by the complement C5b-9 complex, and it modulates antithrombin III-thrombin action in blood coagulation. The protein consists of three domains: the N-terminal Somatomedin B domain (1-39), a central domain with hemopexin homology (131-342) and a C-terminal domain (347-459) also with hemopexin homology. The Somatomedin B domain binds to Plasminogen Activator Inhibitor-1 (PAI-1) and is responsible for PAI-1 stabilization. Furthermore, the Somatomedin B domain can also interact with the urokinase plasminogen activator receptor (uPAR). Vitronectin-uPAR interaction is required and sufficient to initiate downstream changes in cell morphology, migration and signal transduction. High plasma levels of both PAI-1 and uPAR have been shown to correlate with a negative prognosis for cancer patients. Additionally, vitronectin is a component of platelets and is as such involved in hemostasis. Amino acid 45-47 (RGD) are capable of binding to membrane bound integrins, which serve to anchor cells to the extracellular matrix. Vitronectin in plasma is an inactive monomer form. In contrast, tissue vitronectin is an active multimeric form and is able to interact with various matrix ligands like proteoglycans and collagen. Mice with a genetic deletion of vitronectin show delayed wound healing, suggesting an important role of vitronectin in tissue remodeling after injury.Synonyms: S-protein, Serum-spreading factor, V75, VTN
    ID gène
    7448
    NCBI Accession
    NP_000629
    UniProt
    P04004
    Pathways
    Autophagy, Smooth Muscle Cell Migration
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