ZBTB4 anticorps

N° du produit ABIN1109539

Détail du produit anti-ZBTB4 anticorps

Antigène: ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZBTB4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts with 105 kDa ZBTB4 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A

Immunogène: Synthetic peptide derived from an internal domain of Human ZBTB4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine, 2 % Sucrose, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ZBTB4

Antigène: ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))

Autre désignation: ZBTB4 (ZBTB4 Produits)

Synonymes: anticorps KAISO-L1, anticorps ZNF903, anticorps 2310026P19Rik, anticorps 9230111I22Rik, anticorps RP23-422L16.16, anticorps mKIAA1538, anticorps zinc finger and BTB domain containing 4, anticorps ZBTB4, anticorps Zbtb4

Sujet: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.Synonyms: KAISO-L1, KAISO-like zinc finger protein 1, KIAA1538, Zinc finger and BTB domain-containing protein 4

ID gène: 57659

NCBI Accession: NP_001122305