IL1RN anticorps (Biotin)

N° du produit ABIN112013

Détail du produit anti-IL1RN anticorps (Biotin)

Antigène: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL1RN est conjugé à/à la Biotin

Application: Enzyme Immunoassay (EIA)

Purification: Affinity Chromatography.

Immunogène: Recombinant Human IL-1Ra.

Clone: 1384-92

Isotype: IgG1

Information d'application

Indications d'application: Suitable for ELISA (2 /mL).

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 0.5 mL distilled water (stock solution).

Concentration: 0.4 mg/mL

Buffer: Phosphate buffered saline, pH 7.2 containing 0.01 % Thimerosal as a preservative and no stabilizer.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Can be shipped at 2-8 °C.

Détails sur IL1RN

Antigène: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Autre désignation: IL1RN / IL1RA (IL1RN Produits)

Synonymes: anticorps DIRA, anticorps ICIL-1RA, anticorps IL-1RN, anticorps IL-1ra, anticorps IL-1ra3, anticorps IL1F3, anticorps IL1RA, anticorps IRAP, anticorps MVCD4, anticorps IRAP1, anticorps IL1RN, anticorps IL-1RA, anticorps F630041P17Rik, anticorps interleukin 1 receptor antagonist, anticorps interleukin 1 receptor antagonist-like, anticorps IL1RN, anticorps Il1rn, anticorps IL1RNL

Sujet: The interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring molecule that shares homology with IL-1alpha and IL-1beta. It binds competitively to IL-1 receptors type I and type II with the same affinity as does IL-1, but does not induce any intracellular response. Two structural variants of IL-1Ra have been described: a 17 kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18- kDa form that remains in the cytoplasm of keratinocytes and other epithelial cells, monocytes, and fibroblasts (icIL-1Ra). An additional 16- kDa intracellular isoform of IL-1Ra has been described in neutrophils, monocytes, and hepatic cells. Both of the major isoforms of IL-1Ra are transcribed from the same gene through the use of alternative first exons. The production of IL-1Ra is stimulated by many substances including adherent IgG, other cytokines, and bacterial or viral components. The tissue distribution of IL-1Ra in mice indicates that sIL-1Ra is found predominantly in peripheral blood cells, lung, spleen, and liver, while icIL-1Ra is found in large amounts in skin. Studies in transgenic and knockout mice indicate that IL-1Ra is important in host defence against endotoxin-induced injury. IL-1Ra is produced by hepatic cells with the characteristics of an acute phase protein. Endogenous IL-1Ra is produced in numerous experimental animal models of disease as well as in human autoimmune and chronic inflammatory diseases. The use of neutralizing anti-IL-1Ra antibodies has demonstrated that endogenous IL-1Ra is an important natural antiinflammatory protein in arthritis, colitis, and granulomatous pulmonary disease.Synonyms: ICIL-1RA, IL-1RN, IL-1ra, IL1 inhibitor, IL1F3, IRAP, Interleukin-1 receptor antagonist protein

ID gène: 9606

UniProt: P18510

Pathways: Signalisation NF-kappaB, Hormone Transport, Cancer Immune Checkpoints