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VEGFR2/CD309 anticorps (C-Term)

VEGFR2 Reactivité: Humain, Souris, Rat IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN115389
  • Antigène Voir toutes VEGFR2/CD309 (VEGFR2) Anticorps
    VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
    Épitope
    • 37
    • 36
    • 27
    • 22
    • 20
    • 20
    • 16
    • 16
    • 14
    • 10
    • 10
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 314
    • 205
    • 145
    • 18
    • 9
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 309
    • 55
    • 18
    • 2
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 304
    • 83
    Polyclonal
    Conjugué
    • 167
    • 35
    • 21
    • 15
    • 15
    • 13
    • 13
    • 13
    • 11
    • 11
    • 11
    • 11
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp VEGFR2/CD309 est non-conjugé
    Application
    • 241
    • 137
    • 101
    • 91
    • 63
    • 34
    • 26
    • 24
    • 24
    • 14
    • 13
    • 12
    • 9
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody reacts with a 180 kDa protein, known as Flk-1/KDR/Vascular endothelial growth factor receptor 2.
    Cellular Localization:Cytoplasmic.
    Purification
    Purified
    Immunogène
    A synthetic peptide derived from the C-terminus of the precursor form of the Human Flk-1
    Top Product
    Discover our top product VEGFR2 Anticorps primaire
  • Indications d'application
    Western Blotting. Immunohistochemistry on Paraffin Sections: Use a 1/50-1/100 dilution in an ABC method(incubation time: 30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended positive control: Angiosarcoma.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
    Autre désignation
    CD309 / VEGFR-2 / Flk-1 (VEGFR2 Produits)
    Synonymes
    anticorps CD309, anticorps FLK1, anticorps VEGFR, anticorps VEGFR2, anticorps 6130401C07, anticorps Flk-1, anticorps Flk1, anticorps Krd-1, anticorps Ly73, anticorps VEGFR-2, anticorps sVEGFR-2, anticorps Vegfr-2, anticorps FLK-1, anticorps flk-1, anticorps vegfr-2, anticorps KDR, anticorps FLK/KDR, anticorps flk1, anticorps flk1b, anticorps kdrb, anticorps si:busm1-205d10.1, anticorps si:ch211-254j6.1, anticorps si:ch211-278f21.4, anticorps wu:fc31a09, anticorps fk52c05, anticorps flk, anticorps kdr, anticorps kdra, anticorps vegfr2, anticorps vegfr4, anticorps vegr2, anticorps wu:fk52c05, anticorps kinase insert domain receptor, anticorps kinase insert domain protein receptor, anticorps vascular endothelial growth factor receptor kdr-like, anticorps kinase insert domain receptor (a type III receptor tyrosine kinase), anticorps kinase insert domain receptor like, anticorps KDR, anticorps Kdr, anticorps LOC100136647, anticorps kdr, anticorps kdrl
    Sujet
    CD309 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
    ID gène
    3791
    NCBI Accession
    NP_002244
    UniProt
    P35968
    Pathways
    Signalisation RTK, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
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