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Resistin anticorps

RETN Reactivité: Humain WB, EIA Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN115515
  • Antigène Voir toutes Resistin (RETN) Anticorps
    Resistin (RETN)
    Reactivité
    • 86
    • 31
    • 11
    • 7
    • 1
    • 1
    Humain
    Hôte
    • 90
    • 23
    • 10
    • 4
    • 3
    Chèvre
    Clonalité
    • 108
    • 23
    Polyclonal
    Conjugué
    • 76
    • 19
    • 12
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Resistin est non-conjugé
    Application
    • 89
    • 57
    • 37
    • 14
    • 10
    • 10
    • 9
    • 9
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    The antibody recognizes human Resistin. Other species not tested.
    Purification
    Immunoaffinity chromatography on a column with immobilized recombinant Human Resistin
    Immunogène
    Recombinant Human Resistin (Source of antigen: E. coli)
    Top Product
    Discover our top product RETN Anticorps primaire
  • Indications d'application
    ELISA. Western blotting.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Add 0.1 mL of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
    Buffer
    Lyophilized from 1 mg/mL in 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2, AZIDE FREE
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    Do Not Use Sodium Azide as Preservative.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing. Dilute only prior to immediate use
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store vial at 2-8 °C prior to restoration. For extended storage add glycerol to 50% and then aliquot contents and freeze at -20 °C or below. Centrifuge product if not completely clear after standing at room temperature. This antibody is stable for one month at 2-8 °C as an undiluted liquid.
  • Antigène
    Resistin (RETN)
    Autre désignation
    Resistin (RETN Produits)
    Synonymes
    anticorps RETN, anticorps ADSF, anticorps FIZZ3, anticorps RETN1, anticorps RSTN, anticorps XCP1, anticorps Fizz3, anticorps Rstn, anticorps Xcp4, anticorps resistin, anticorps RETN, anticorps Retn
    Sujet
    Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue-Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a prepeptide, and its hydrofobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26. Resistin may be an important link between obesity and insulin resistance. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulace glucose uptake. They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severly suppressed in obesity and is stimulated by several antidiabetic drugs. Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression. Recent studies have shown that human resistin is expressed also in macrophages and may be a novel link between inflammation and insulin resistance.Synonyms: ADSF, Adipose tissue-specific secretory factor, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3, FIZZ3, HXCP1, RETN, RSTN
    ID gène
    56729
    NCBI Accession
    NP_001180303
    UniProt
    Q9HD89
    Pathways
    Feeding Behaviour, Smooth Muscle Cell Migration
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