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Endoglin anticorps (AA 22-586)

ENG Reactivité: Humain WB, FACS, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN115699
  • Antigène Voir toutes Endoglin (ENG) Anticorps
    Endoglin (ENG)
    Épitope
    • 16
    • 14
    • 12
    • 12
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 22-586
    Reactivité
    • 178
    • 67
    • 44
    • 17
    • 10
    • 3
    • 2
    • 1
    Humain
    Hôte
    • 107
    • 93
    • 21
    • 1
    • 1
    Lapin
    Clonalité
    • 115
    • 107
    • 1
    Polyclonal
    Conjugué
    • 93
    • 28
    • 26
    • 26
    • 15
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Endoglin est non-conjugé
    Application
    • 153
    • 134
    • 62
    • 58
    • 37
    • 21
    • 19
    • 15
    • 15
    • 13
    • 13
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    Purification
    Protein A Chromatography
    Immunogène
    Recombinant Human soluble CD105/Endoglin (aa. 22 (Glu) to 586 (Leu)) derived from Insect Cells
    Top Product
    Discover our top product ENG Anticorps primaire
  • Indications d'application
    Elisa (1-15 μg/mL). Western blot (1-2 μg/mL with the appropriate secondary reagents). FACS analysis and cell sorting (2-5 μg/mL together with the appropriate secondaryreagents).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in sterile water to a concentration of 0.1-1.0 mg/mL
    Buffer
    PBS, pH 7.4 without preservatives
    Agent conservateur
    Without preservative
    Conseil sur la manipulation
    This product is photosensitive and should be protected from light
    Stock
    4 °C
    Stockage commentaire
    Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
  • Antigène
    Endoglin (ENG)
    Autre désignation
    CD105 / Endoglin (ENG Produits)
    Synonymes
    anticorps ENG, anticorps MGC137842, anticorps DKFZp469D0419, anticorps END, anticorps HHT1, anticorps ORW1, anticorps AI528660, anticorps AI662476, anticorps CD105, anticorps S-endoglin, anticorps endoglin, anticorps ENG, anticorps Eng
    Sujet
    Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1
    ID gène
    9606
    UniProt
    P17813
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