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AIM2 anticorps (AA 1-186)

AIM2 Reactivité: Humain WB, ICC Hôte: Souris Monoclonal 3B10 unconjugated
N° du produit ABIN1169341
  • Antigène Voir toutes AIM2 Anticorps
    AIM2 (Absent in Melanoma 2 (AIM2))
    Épitope
    • 16
    • 10
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-186
    Reactivité
    • 68
    • 24
    • 18
    • 3
    • 2
    • 1
    Humain
    Hôte
    • 56
    • 11
    • 2
    Souris
    Clonalité
    • 61
    • 8
    Monoclonal
    Conjugué
    • 38
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AIM2 est non-conjugé
    Application
    • 62
    • 34
    • 33
    • 22
    • 13
    • 13
    • 13
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC)
    Specificité
    Recognizes human AIM2.
     Réactivité croisée
    Humain
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Pureté
    >95 % (SDS-PAGE)
    Immunogène
    Human AIM2 (aa 1-186).
    Clone
    3B10
    Isotype
    IgG1
    Top Product
    Discover our top product AIM2 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Hornung, Ablasser, Charrel-Dennis, Bauernfeind, Horvath, Caffrey, Latz, Fitzgerald: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." dans: Nature, Vol. 458, Issue 7237, pp. 514-8, (2009) (PubMed).

    Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." dans: Nature, Vol. 458, Issue 7237, pp. 509-13, (2009) (PubMed).

    Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." dans: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, (2004) (PubMed).

  • Antigène
    AIM2 (Absent in Melanoma 2 (AIM2))
    Autre désignation
    AIM2 (AIM2 Produits)
    Synonymes
    anticorps AIM2, anticorps PYHIN4, anticorps Gm1313, anticorps Ifi210, anticorps absent in melanoma 2, anticorps AIM2, anticorps Aim2
    Sujet
    AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.
    UniProt
    O14862
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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