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IKKi/IKKe anticorps (pThr501)

IKBKE Reactivité: Humain WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN116937
  • Antigène Voir toutes IKKi/IKKe (IKBKE) Anticorps
    IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))
    Épitope
    • 15
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr501
    Reactivité
    • 67
    • 26
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 77
    • 6
    Lapin
    Clonalité
    • 68
    • 15
    Polyclonal
    Conjugué
    • 35
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IKKi/IKKe est non-conjugé
    Application
    • 67
    • 38
    • 22
    • 16
    • 16
    • 14
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Séquence
    R-S-R-L-R-pT-L-A-E-V-L
    Specificité
    This phospho specific polyclonal antibody is specific for phosphorylated pThr501 IKKE. Reactivity with non-phosphorylated IKKE is minimal.
    Purification
    Immunoaffinity Chromatography against the phosphopeptide and cross adsorption against the non-phosphorylated form of the peptide followed by non-adsorption against a non-specific peptide backbone to further reduce non-specific reactivity.
    Immunogène
    IKKE phosphopeptide corresponding to a region of the human protein surrounding pThr501 conjugated to KLH. Genename: IKKe
    Top Product
    Discover our top product IKBKE Anticorps primaire
  • Indications d'application
    This phospho specific polyclonal antibody reacts with phosphorylated human IKKE atpT501 and shows minimal reactivity by Western blot with non-phosphorylated IKKE andminimal reactivity by ELISA against the non-phosphorylated form of the immunizingpeptide. Although not tested, this antibody is likely functional in Immunohistochemistryand Immunoprecipitation.
    Restrictions
    For Research Use only
  • Concentration
    1.15 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 with 0.09 % Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))
    Autre désignation
    IKBKE / IKKE (IKBKE Produits)
    Synonymes
    anticorps zgc:100844, anticorps IKBKE, anticorps MGC130907, anticorps IKK-E, anticorps IKK-i, anticorps IKKE, anticorps IKKI, anticorps AW558201, anticorps IKKepsilon, anticorps Ikki, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, anticorps inhibitor of nuclear factor kappa B kinase subunit epsilon, anticorps inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog, anticorps inhibitor of kappaB kinase epsilon, anticorps IKBKE, anticorps ikbke, anticorps ikbke.L, anticorps Ikbke
    Sujet
    Nuclear Factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during the activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cytoplasm of the cell, which inhibit NF-κB activity. IκB proteins are phosphorylated by an IκB kinase complex consisting of at least three proteins, IKKa, IKKb, and IKKg. Isolated from a cDNA library of LPS-stimulated mouse macrophage cells, a novel molecule in the IKK complex has been recently identified and designated IKKi and/or IKKe. IKKe is required for the activation of NF-κB by mitogens and T cell receptors but not by TNFa or IL-1. LPS increases the IKKe mRNA level in mouse macrophage cell lines. This protein has significant sequence homology with kinase domains of IKKa and IKKb. Overexpression of wild type IKKe in cells phosphorylates Ser32 and Ser36 of IκBa.Synonyms: I kappa-B kinase epsilon, IKK-E, IKK-I, IKK-epsilon, IKKI, Inducible I kappa-B kinase, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, KIAA0151
    ID gène
    9641
    NCBI Accession
    NP_001180250
    UniProt
    Q14164
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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