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Cullin 3 anticorps (N-Term)

CUL3 Reactivité: Humain, Souris WB, IHC (p), IP, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN117949
  • Antigène Voir toutes Cullin 3 (CUL3) Anticorps
    Cullin 3 (CUL3)
    Épitope
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-12, N-Term
    Reactivité
    • 54
    • 23
    • 19
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 51
    • 2
    • 1
    Lapin
    Clonalité
    • 48
    • 6
    Polyclonal
    Conjugué
    • 33
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cullin 3 est non-conjugé
    Application
    • 26
    • 16
    • 13
    • 13
    • 13
    • 6
    • 6
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
    Séquence
    Human Cullin 3 (768 aa 88.9 kDa): 1 msnlskgtgs rkdtkmrira fpmtmdekyv nsiwdllkna iqeiqrknns glsfeelyrn 61 aytmvlhkhg eklytglrev vtehlinkvr edvlnslnnn flqtlnqawn dhqtamvmir 121 dilmymdrvy vqqnnvenvy nlgliifrdq vvrygcirdh lrqtlldmia rerkgevvdr 181 gairnacqml milglegrsv yeedfeapfl emsaeffqme sqkflaensa svyikkvear 241 ineeiervmh cldksteepi vkvverelis khmktiveme nsglvhmlkn gktedlgcmy 301 klfsrvpngl ktmcecmssy lreqgkalvs eegegknpvd yiqglldlks rfdrfllesf 361 nndrlfkqti agdfeyflnl nsrspeylsl fiddklkkgv kglteqevet ildkamvlfr 421 fmqekdvfer yykqhlarrl ltnksvsdds eknmisklkt ecgcqftskl egmfrdmsis 481 nttmdefrqh lqatgvslgg vdltvrvltt gywptqsatp kcnippaprh afeifrrfyl 541 akhsgrqltl qhhmgsadln atfygpvkke dgsevgvgga qvtgsntrkh ilqvstfqmt 601 ilmlfnnrek ytfeeiqqet diperelvra lqslacgkpt qrvltkepks keienghift 661 vndqftsklh rvkiqtvaak qgesdperke trqkvdddrk heieaaivri mksrkkmqhn 721 vlvaevtqql karflpspvv ikkrieglie reylartped rkvytyva
    Specificité
    This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human Cullin 3. Cross reactivity is expected against mouse Cul3 based on sequence homology. Cross reactivity with other human cullins is unlikely based on sequence homology.
    Purification
    Delipidation and defibrination.
    Immunogène
    Synthetic peptide corresponding to amino acids 1-12 of Human Cul3 (N-terminus) coupled to KLH.
    Top Product
    Discover our top product CUL3 Anticorps primaire
  • Indications d'application
    Western blot: This antibody reacts with human Cul3 (1/500-1/1,000, An 88.9 kDa bandcorresponding to human Cul3 is detected, Most cell lines expressing Cul3 can be used as apositive control).
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    85.0 mg/mL (by Refractometry)
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for up to one month or at -20 °C for longer.
  • Chuang, Huang, Hsieh, Jung, Ye, Du, Lu, Cho, Hsiao, Hsu, Lin: "Sporadic paediatric and adult Burkitt lymphomas share similar phenotypic and genotypic features." dans: Histopathology, Vol. 52, Issue 4, pp. 427-35, (2008) (PubMed).

  • Antigène
    Cullin 3 (CUL3)
    Autre désignation
    Cullin-3 (CUL3 Produits)
    Synonymes
    anticorps CUL-3, anticorps Cullin-3, anticorps CUL-3-A, anticorps Cullin-3-A, anticorps cul3, anticorps cul3a, anticorps CUL-3-B, anticorps Cullin-3-B, anticorps cul3b, anticorps wu:fc37e01, anticorps CUL3, anticorps ATCUL3, anticorps ATCUL3A, anticorps CUL3A, anticorps T24P13.25, anticorps cullin 3, anticorps cullin 3A, anticorps PHA2E, anticorps AI467304, anticorps AW146203, anticorps mKIAA0617, anticorps cullin 3, anticorps cullin 3 L homeolog, anticorps cullin 3 S homeolog, anticorps cullin-3, anticorps Cullin-3 (CUL-3), anticorps cullin 3a, anticorps CULlin, anticorps CUL3, anticorps cul3, anticorps cul3.L, anticorps cul3.S, anticorps PTRG_11586, anticorps Smp_117580, anticorps cul3a, anticorps Cul3, anticorps cul-3
    Sujet
    Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Unlike Cul1 and Cul2, Cul3 seems not to be a part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.Synonyms: CUL-3, CUL3, KIAA0617
    ID gène
    8452
    NCBI Accession
    NP_003581
    UniProt
    Q13618
    Pathways
    M Phase
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