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ING4 anticorps (Isoform 1)

ING4 Reactivité: Humain, Souris, Rat, Chien, Poulet, Singe WB, EIA Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN118054
  • Antigène Voir toutes ING4 Anticorps
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    Épitope
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 164-175, Isoform 1
    Reactivité
    • 30
    • 16
    • 13
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet, Singe
    Hôte
    • 26
    • 3
    • 1
    Chèvre
    Clonalité
    • 29
    • 1
    Polyclonal
    Conjugué
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ING4 est non-conjugé
    Application
    • 18
    • 13
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Séquence
    Protein sequence for Human p29 ING4 isoform 1, 249 aa, predicted MW 28.5 kDa: 1 maagmylehy ldsienlpfe lqrnfqlmrd ldqrtedlka eidklateym ssarslssee 61 klallkqiqe aygkckefgd dkvqlamqty emvdkhirrl dtdlarfead lkekqiessd 121 ydsssskgkk kgrtqkekka ararskgkns deeapktaqk klklvrtspe ygmpsvtfgs 181 vhpsdvldmp vdpneptycl chqvsygemi gcdnpdcsie wfhfacvglt tkprgkwfcp 241 rcsqerkkk Protein sequence for Human p29 ING4 isoform 2, 47 aa, predicted MW 5.6 kDa: 1 maagmylehy ldsienlpfe lqrnfqlmrd ldqrteeald tissleh
    Specificité
    Reactivity occurs against human p29 ING4 protein. 100 % homology is on record for this protein from human, dog, rat, and mouse. Cross reactivity with p29 ING4 protein from chimpanzee and chicken sources is also expected based on high homology (one amino acid change in sequence) by BLAST. Reactivity with p29 ING4 proteins from other sources is not known.
    Purification
    Immunoaffinity chromatography.
    Immunogène
    A synthetic peptide corresponding aa 164-175 of Human p29 ING4 protein. This sequence only shows homology to isoform 1 for ING4. Genename: ING4
    Top Product
    Discover our top product ING4 Anticorps primaire
  • Indications d'application
    Antibody R1606P has been tested for use in ELISA (1: 3,000-1: 12,000) against theimmunizing peptide. Specific conditions for Western blotting (1: 500-1: 3,000) reactivity
    Restrictions
    For Research Use only
  • Concentration
    1.28 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, containing 0.01 % (w/v) Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    This product is photosensitive and should be protected from light
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 2-8 °C. DO NOT FREEZE!
  • Wang, He, Wang, Wang, Zhai, Zhou, Zhang, Zhai, Feng, Han: "[Impact of Donor KIR2DS5 Genotype on Outcome Following Haploidentical Hematopoietic Stem Cell Transplantation.]" dans: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, Vol. 16, Issue 1, pp. 111-5, (2008) (PubMed).

    Kim, Choi, Park, Han, Kim, Chu, Kim: "Endometrial stromal sarcoma of the small bowel: a case report and review of literature." dans: Annals of diagnostic pathology, Vol. 12, Issue 2, pp. 128-33, (2008) (PubMed).

  • Antigène
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    Autre désignation
    ING4 (ING4 Produits)
    Synonymes
    anticorps wu:fb11d09, anticorps wu:fb50e02, anticorps zgc:110619, anticorps ING4, anticorps my036, anticorps p29ING4, anticorps D6Wsu147e, anticorps D6Xrf92, anticorps inhibitor of growth family, member 4, anticorps inhibitor of growth family member 4, anticorps ing4, anticorps ING4, anticorps Ing4
    Sujet
    P29 ING4 is a tumor suppressor protein similar to ING1 that may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA. p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed. The accession number listed below is for variant (1) that encodes the longest isoform.Synonyms: Inhibitor of growth protein 4, My036, p29ING4
    ID gène
    51147
    NCBI Accession
    NP_001121054
    UniProt
    Q9UNL4
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