ITGB1 anticorps

N° du produit ABIN120030

Détail du produit anti-ITGB1 anticorps

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGB1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Purification: Ammonium Sulphate Precipitation

Immunogène: Purified Human beta-1 integrin. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the NS1 mouse myeloma cell line.

Clone: JB1B

Isotype: IgG2a

Information d'application

Indications d'application: Flow cytometry: 1 μg/10^6cells. Immunoprecipitation: 1 - 5 μg/mL. Immunohistochemistry on frozen sections: 5 μg/mL. ELISA: 0.1-1 μg/mL. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-ITGB1 (ABIN120030)

Haglund, Tillgren, Addis, Wenglén, Recklies, Heinegård: "Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment." dans: The Journal of biological chemistry, Vol. 286, Issue 5, pp. 3925-34, (2011) (PubMed).

Détails sur ITGB1

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Autre désignation: CD29 / Integrin beta-1 (ITGB1 Produits)

Synonymes: anticorps CD29, anticorps FNRB, anticorps GPIIA, anticorps MDF2, anticorps MSK12, anticorps VLA-BETA, anticorps VLAB, anticorps 4633401G24Rik, anticorps AA409975, anticorps AA960159, anticorps ENSMUSG00000051907, anticorps Fnrb, anticorps Gm9863, anticorps gpIIa, anticorps cd29, anticorps fnrb, anticorps gpiia, anticorps itgb1, anticorps mdf2, anticorps msk12, anticorps vla-beta, anticorps vlab, anticorps itgb1-a, anticorps itgb1-b, anticorps integrin subunit beta 1, anticorps integrin beta 1 (fibronectin receptor beta), anticorps integrin subunit beta 1 S homeolog, anticorps integrin beta 1, anticorps integrin subunit beta 1 L homeolog, anticorps ITGB1, anticorps Itgb1, anticorps itgb1.S, anticorps LOC100009173, anticorps itgb1.L

Sujet: Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FNRB, Fibronectin receptor subunit beta, ITGB1, Integrin VLA-4 subunit beta, MDF2, MSK12

ID gène: 9606

UniProt: P05556

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome