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KLRK1 anticorps

KLRK1 Reactivité: Humain FACS, IP, IHC (fro) Hôte: Souris Monoclonal 1D11 unconjugated
N° du produit ABIN120294
  • Antigène Voir toutes KLRK1 Anticorps
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Reactivité
    • 58
    • 37
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 54
    • 21
    • 5
    • 5
    • 2
    • 1
    Souris
    Clonalité
    • 53
    • 33
    • 2
    Monoclonal
    Conjugué
    • 35
    • 10
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KLRK1 est non-conjugé
    Application
    • 52
    • 46
    • 16
    • 16
    • 15
    • 14
    • 13
    • 11
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This antibody is specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6). We recommend the use of SM2260LE for such studies.
    Purification
    Affinity Chromatography on Protein G.
    Immunogène
    NKL cells. Spleen cells from immunised RBF/DnJ mice were fused with cells of the p3 mouse myeloma cell line.
    Clone
    1D11
    Isotype
    IgG1
    Top Product
    Discover our top product KLRK1 Anticorps primaire
  • Indications d'application
    Flow Cytometry: Use 10 μL of 1/100 diluted antibody to label 106 cells in 100 μL. Immunoprecipitation. Immunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Autre désignation
    CD314 / KLRK1 (KLRK1 Produits)
    Synonymes
    anticorps KLRK1, anticorps NKG2D, anticorps CD314, anticorps D12S2489E, anticorps KLR, anticorps NKG2-D, anticorps D6H12S2489E, anticorps Nkg2d, anticorps Nkrp2, anticorps killer cell lectin like receptor K1, anticorps killer cell lectin-like receptor subfamily K, member 1, anticorps NKG2D protein, anticorps KLRK1, anticorps Klrk1, anticorps NKG2D
    Sujet
    CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding t °CD314 results in NK cell activation and potent costimulation of effector T cells.Synonyms: D12S2489E, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2D
    ID gène
    100528032
    NCBI Accession
    NP_001186734
    UniProt
    P26718
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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