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Factor VIII anticorps

F8 Reactivité: Humain, Porc WB, EIA, RIA Hôte: Souris Monoclonal RFFVIIIC-8 unconjugated
N° du produit ABIN120341
  • Antigène Voir toutes Factor VIII (F8) Anticorps
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    Reactivité
    • 94
    • 59
    • 30
    • 17
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    Humain, Porc
    Hôte
    • 88
    • 20
    • 4
    • 2
    Souris
    Clonalité
    • 95
    • 19
    Monoclonal
    Conjugué
    • 49
    • 15
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp Factor VIII est non-conjugé
    Application
    • 54
    • 42
    • 39
    • 39
    • 24
    • 11
    • 10
    • 10
    • 10
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)
    Specificité
    Clone RFFVIIIC/8 is a very potent coagulation inhibitor. This antibody recognizes an epitope towards the N-terminus of full length Factor VIII. It also recognises the 210 kDa, 90 kDa and 40 kDa cleavage products. This clone does not cross-react with von Willebrand factor.
    Aucune reactivité croisée
    Souris, Chien, Rat (Rattus)
    Réactivité croisée (Details)
    Species reactivity (tested):Human and Pig.
    Purification
    Affinity Chromatography on Protein G from tissue culture supernatant
    Immunogène
    Affinity purified Human Factor VIII
    Clone
    RFFVIIIC-8
    Isotype
    IgG1
    Top Product
    Discover our top product F8 Anticorps primaire
  • Indications d'application
    ELISA: 1:200 - 1:2000. Western blotting: 1:20 - 1:200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, 0.09 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    Abstract
    F8 Produits
    Synonymes
    anticorps fb61d02, anticorps wu:fb61d02, anticorps Cf-8, anticorps Cf8, anticorps FVIII, anticorps AHF, anticorps DXS1253E, anticorps F8B, anticorps F8C, anticorps HEMA, anticorps coagulation factor VIIi, anticorps coagulation factor VIII, anticorps coagulation factor VIII, procoagulant component, anticorps f7i, anticorps F8
    Sujet
    Human Factor VIII is an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and crosslinks to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A, a disorder characterised by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries.Synonyms: AHF, Antihemophilic factor, F8C, Procoagulant component
    ID gène
    2157
    NCBI Accession
    NP_000123
    UniProt
    P00451
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