MAPK8IP1 anticorps

N° du produit ABIN127294

Détail du produit anti-MAPK8IP1 anticorps

Antigène: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPK8IP1 est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody recognizes 78 kDa JIP1.

Purification: Protein A purified

Immunogène: Synthetic peptide from mouse JIP1.

Information d'application

Indications d'application: Western Blot: 0.5-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 2 mg/mL

Buffer: PBS containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Détails sur MAPK8IP1

Antigène: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Autre désignation: MAPK8IP1 / JIP1 (MAPK8IP1 Produits)

Synonymes: anticorps IB1, anticorps JIP-1, anticorps Jip1, anticorps Prkm8ip, anticorps Skip, anticorps mjip-2a, anticorps JIP1, anticorps Jip-1, anticorps Mapk8ip, anticorps PRKM8IP, anticorps mitogen-activated protein kinase 8 interacting protein 1, anticorps MAPK8IP1, anticorps Mapk8ip1

Sujet: JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNKbinding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.Synonyms: C-jun-amino-terminal kinase-interacting protein 1, IB1, Islet-brain 1, JIP-1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, Mitogen-activated protein kinase 8-interacting protein 1, PRKM8IP

ID gène: 9479

NCBI Accession: NP_005447

UniProt: Q9UQF2