FKBP8 anticorps

N° du produit ABIN127298

Détail du produit anti-FKBP8 anticorps

Antigène: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FKBP8 est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody recognizes a ~40 kDa band of FKBP38.

Purification: Protein A chromatography

Immunogène: Synthetic peptide surrounding amino acid 344 of mouse FKBP38

Information d'application

Indications d'application: Western Blot: 0.5 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: BPS containing 0.1 % BSA, 20 % glycerol, and 0.02 % thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur FKBP8

Antigène: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Autre désignation: FKBP8 / FKBP38 (FKBP8 Produits)

Synonymes: anticorps FKBP8, anticorps fkbp8, anticorps 38kDa, anticorps FKBP-38, anticorps FKBP-8, anticorps Fkbp38, anticorps zgc:77672, anticorps FKBP38, anticorps FKBPr38, anticorps FK506 binding protein 8, anticorps FK506 binding protein 8 L homeolog, anticorps FKBP8, anticorps fkbp8, anticorps Fkbp8, anticorps fkbp8.L

Sujet: FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl- xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.Synonyms: 38 kDa FK506-binding protein, FK506-binding protein 8, Peptidyl-prolyl cis-trans isomerase FKBP8, Rotamase

ID gène: 23770

NCBI Accession: NP_036313

UniProt: Q14318

Pathways: Autophagy