LRP5 anticorps

N° du produit ABIN127323

Détail du produit anti-LRP5 anticorps

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP5 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity Chromatography

Immunogène: Synthetic peptide surrounding amino acid 437 of Human LRP.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.5-4.0 μg/mL. Jurkat cell lysate can be used as a Positive Control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal as preservative

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at -20 °C or at -70 °C (in aliquots) for long term storage.

Références pour anticorps anti-LRP5 (ABIN127323)

Moon, Lee, Kim, Cho, Lee, Kim, Park, Cho, Lee, Oh: "Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot." dans: PLoS ONE, Vol. 11, Issue 1, pp. e0146710, (2016) (PubMed).

Wiese, Gerlach, Popp, Matuszak, Mahapatro, Castiglione, Chakravortty, Willam, Hensel, Bogdan, Jantsch: "Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages." dans: Infection and immunity, Vol. 80, Issue 4, pp. 1455-66, (2012) (PubMed).

Del Valle-Pérez, Arqués, Vinyoles, de Herreros, Duñach: "Coordinated action of CK1 isoforms in canonical Wnt signaling." dans: Molecular and cellular biology, Vol. 31, Issue 14, pp. 2877-88, (2011) (PubMed).

Casagolda, Del Valle-Pérez, Valls, Lugilde, Vinyoles, Casado-Vela, Solanas, Batlle, Reynolds, Casal, de Herreros, Duñach: "A p120-catenin-CK1epsilon complex regulates Wnt signaling." dans: Journal of cell science, Vol. 123, Issue Pt 15, pp. 2621-31, (2010) (PubMed).

Danieli-Betto, Peron, Germinario, Zanin, Sorci, Franzoso, Sandonà, Betto: "Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration." dans: American journal of physiology. Cell physiology, Vol. 298, Issue 3, pp. C550-8, (2010) (PubMed).

Détails sur LRP5

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Autre désignation: LRP5 + LRP6 (LRP5 Produits)

Synonymes: anticorps Xlrp5, anticorps bmnd1, anticorps evr1, anticorps evr4, anticorps hbm, anticorps lr3, anticorps lrp5-A, anticorps lrp7, anticorps oppg, anticorps ops, anticorps opta1, anticorps vbch2, anticorps LRP5, anticorps LRP6, anticorps BMND1, anticorps EVR1, anticorps EVR4, anticorps HBM, anticorps LR3, anticorps LRP7, anticorps OPPG, anticorps OPS, anticorps OPTA1, anticorps VBCH2, anticorps mKIAA4142, anticorps low-density lipoprotein receptor-related protein 5, anticorps LDL receptor related protein 5, anticorps LDL receptor related protein 5 L homeolog, anticorps low density lipoprotein receptor-related protein 5, anticorps LDL receptor related protein 5 like, anticorps LOC100147353, anticorps LRP5, anticorps lrp5.L, anticorps lrp5, anticorps Lrp5, anticorps LRP5L

Sujet: LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily, which were found to be involved in the canonical Want signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin, leading Axin degradation and beta-catenin stabilization.Synonyms: LRP5, LRP6, LRP7, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 6

Pathways: Signalisation WNT, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation