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CD8 alpha anticorps (FITC)

CD8A Reactivité: Souris FACS Hôte: Rat Monoclonal 53-6-7 FITC
N° du produit ABIN135120
  • Antigène Voir toutes CD8 alpha (CD8A) Anticorps
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Reactivité
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    Hôte
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    Rat
    Clonalité
    • 309
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    Monoclonal
    Conjugué
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    Cet anticorp CD8 alpha est conjugé à/à la FITC
    Application
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    Flow Cytometry (FACS)
    Specificité
    Mouse CD8α, Mr 32-34 kDa
    Attributs du produit
    Rat Anti-Mouse CD8a-FITC
    Immunogène
    Spleen cells or thymocyte membranes
    Clone
    53-6-7
    Isotype
    IgG2a
    Top Product
    Discover our top product CD8A Anticorps primaire
  • Indications d'application
    • Applications: FC - Quality tested , IHC-FS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Depletion - Reported in literature , Block - Reported in literature
    • Working Dilutions: Flow Cytometry Purified (UNLB) antibody 2 g/106 cells FITC and BIOT conjugates 2 g/106 cells AF488 conjugate 1 g/106 cells PE, APC, SPRD, PE/TXRD, CY5, PE/CY5.5, PE/CY7, 0.2 g/106 cells APC/CY5.5, APC/CY7, PACBLU, AF647, and AF700 conjugates For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    Commentaires

    In vivo and in vitro depletion of CD8a+ cells

    Volume d'échantillon
    1 mL
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    0.5 mg or 0.1 mg in 1.0 mL of PBS/Sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect conjugated products from light.
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C
  • Antigène
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Autre désignation
    CD8a (CD8A Produits)
    Synonymes
    anticorps cd8, anticorps LOC100136450, anticorps BB154331, anticorps Ly-2, anticorps Ly-35, anticorps Ly-B, anticorps Lyt-2, anticorps zgc:136643, anticorps CD8, anticorps Leu2, anticorps MAL, anticorps p32, anticorps RHACD8-4, anticorps CD8a molecule, anticorps uncharacterized LOC100125537, anticorps CD8 alpha, anticorps CD8 antigen, alpha chain, anticorps T-cell surface glycoprotein CD8 alpha chain, anticorps Cd8a, anticorps LOC100125537, anticorps LOC100136450, anticorps CD8A, anticorps cd8a, anticorps LOC100126556
    Sujet
    In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an chain (CD8/Lyt-2) and a chain (CD8/Lyt-3), and (ii) a homodimer of two chains. The heterodimer is found on the surface of essentially all thymocytes and the suppressor/cytotoxic subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 without CD8. It has been suggested that CD8+- T cells mature extrathymically, while development of the CD8++ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8+ cells.
    Pathways
    TCR Signaling
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