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LAMP2 anticorps

LAMP2 Reactivité: Humain IHC, FACS Hôte: Souris Monoclonal H4B4 unconjugated
N° du produit ABIN135832
  • Antigène Voir toutes LAMP2 Anticorps
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Reactivité
    • 113
    • 78
    • 36
    • 16
    • 3
    • 3
    • 2
    • 1
    Humain
    Hôte
    • 86
    • 42
    • 34
    Souris
    Clonalité
    • 85
    • 76
    Monoclonal
    Conjugué
    • 60
    • 20
    • 20
    • 15
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LAMP2 est non-conjugé
    Application
    • 115
    • 56
    • 53
    • 37
    • 34
    • 29
    • 28
    • 15
    • 13
    • 13
    • 12
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Specificité
    Human/Rhesus/African Green Monkey CD107b, Mr 100-120 kDa
    Attributs du produit
    Mouse Anti-Human CD107b-UNLB
    Purification
    Purified
    Immunogène
    Human adherent peripheral blood cells
    Clone
    H4B4
    Isotype
    IgG1
    Top Product
    Discover our top product LAMP2 Anticorps primaire
  • Indications d'application
    Working Dilution:
    FACS: 1 µg/10^6 cells
    Representative data are included in this product insert.

    Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
    Volume d'échantillon
    1 mL
    Restrictions
    For Research Use only
  • Buffer
    Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
    Conseil sur la manipulation
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    Stock
    4 °C
  • Eriksson, Wäster, Öllinger: "Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins." dans: Cell death & disease, Vol. 11, Issue 5, pp. 370, (2020) (PubMed).

    Wäster, Eriksson, Vainikka, Rosdahl, Öllinger: "Extracellular vesicles are transferred from melanocytes to keratinocytes after UVA irradiation." dans: Scientific reports, Vol. 6, pp. 27890, (2016) (PubMed).

    Boman, Svensson, Boxer, Rojas, Seeley, Karydas, Miller, Kågedal, Svenningsson: "Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid." dans: Journal of Parkinson's disease, Vol. 6, Issue 2, pp. 307-15, (2016) (PubMed).

    Fritsch, Stephan, Tchikov, Winoto-Morbach, Gubkina, Kabelitz, Schütze: "Cell Fate Decisions to TNF Regulated by K63 Ubiquitination of TNF-Receptor 1." dans: Molecular and cellular biology, (2014) (PubMed).

    Armstrong, Mattsson, Appelqvist, Janefjord, Sandin, Agholme, Olsson, Svensson, Blennow, Zetterberg, Kågedal: "Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease." dans: Neuromolecular medicine, Vol. 16, Issue 1, pp. 150-60, (2014) (PubMed).

  • Antigène
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Autre désignation
    CD107b (LAMP2 Produits)
    Synonymes
    anticorps CD107b, anticorps LAMP-2, anticorps LAMPB, anticorps LGP110, anticorps Lamp-2, anticorps Lamp-2a, anticorps Lamp-2b, anticorps Lamp-2c, anticorps Mac3, anticorps cd107b, anticorps lamp-2, anticorps lampb, anticorps LAMP2, anticorps lamp2, anticorps DKFZp459J126, anticorps LGP-B, anticorps sb:cb587, anticorps wu:fb14a06, anticorps zgc:103532, anticorps lysosomal associated membrane protein 2, anticorps lysosomal-associated membrane protein 2, anticorps lysosomal-associated membrane protein 2 S homeolog, anticorps lysosomal membrane glycoprotein 2, anticorps LAMP2, anticorps Lamp2, anticorps lamp2.S, anticorps lamp2
    Sujet
    CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.
    Pathways
    Autophagy
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