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Proteoglycan 4 anticorps (AA 1151-1250)

PRG4 Reactivité: Souris, Rat, Lapin WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1387463
  • Antigène Voir toutes Proteoglycan 4 (PRG4) Anticorps
    Proteoglycan 4 (PRG4)
    Épitope
    • 14
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1151-1250
    Reactivité
    • 18
    • 18
    • 17
    • 14
    Souris, Rat, Lapin
    Hôte
    • 28
    • 2
    • 1
    Lapin
    Clonalité
    • 29
    • 2
    Polyclonal
    Conjugué
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Proteoglycan 4 est non-conjugé
    Application
    • 26
    • 13
    • 12
    • 12
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Souris, Lapin, Rat
    Homologie
    Human,Dog,Cow
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Lubricin/SZP
    Isotype
    IgG
    Top Product
    Discover our top product PRG4 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Proteoglycan 4 (PRG4)
    Autre désignation
    Lubricin/SZP (PRG4 Produits)
    Synonymes
    anticorps CACP, anticorps HAPO, anticorps JCAP, anticorps MSF, anticorps SZP, anticorps bG174L6.2, anticorps lubricin, anticorps prg4, anticorps si:dkey-97o5.3, anticorps zgc:122988, anticorps PRG4, anticorps DOL54, anticorps proteoglycan 4, anticorps proteoglycan 4b, anticorps proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein), anticorps PRG4, anticorps Prg4, anticorps prg4b
    Sujet

    Synonyms: Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2, CACP, camptodactyly arthropathy coxa vara pericarditis syndrome gene, FLJ32635, HAPO, Jacobs camptodactyly-arthropathy-pericarditis syndrome gene, JCAP, megakaryocyte stimulating factor, MSF, PRG 4, PRG4, proteoglycan 4, Proteoglycan4, Superficial zone proteoglycan, SZP.

    Background: Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights.

    ID gène
    10216
    UniProt
    Q92954
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