DLG1 anticorps (AA 801-904)

N° du produit ABIN1387516

Détail du produit anti-DLG1 anticorps

Antigène: DLG1 (Discs, Large Homolog 1 (DLG1))

Épitope: AA 801-904

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DLG1 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SAP97

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-DLG1 (ABIN1387516)

Lowe, Usowicz, Hodge: "Neuronal overexpression of Alzheimer's disease and Down's syndrome associated DYRK1A/minibrain gene alters motor decline, neurodegeneration and synaptic plasticity in Drosophila." dans: Neurobiology of disease, Vol. 125, pp. 107-114, (2019) (PubMed).

Détails sur DLG1

Antigène: DLG1 (Discs, Large Homolog 1 (DLG1))

Autre désignation: SAP97 (DLG1 Produits)

Synonymes: anticorps DLG1, anticorps Dlgh1, anticorps SAP97, anticorps B130052P05Rik, anticorps E-dlg/SAP97, anticorps SAP-97, anticorps mKIAA4187, anticorps DLGH1, anticorps dJ1061C18.1.1, anticorps hdlg, anticorps discs large MAGUK scaffold protein 1, anticorps discs, large homolog 1 (Drosophila), anticorps DLG1, anticorps Dlg1

Sujet:

Synonyms: Discs large homolog 1, Disks large homolog 1, DLG 1, DLG1, DLG1_HUMAN, DLGH 1, DLGH1, HDLG, Presynaptic protein SAP97, SAP 97, SAP-97, SAP97, Synapse associated protein 97, Synapse-associated protein 97

Background: The discs large (dlg) tumor suppressor gene was first identified in Drosophila through genetic analysis of germline mutations. Several mammalian homologs were subsequently identified and categorized into a protein family designated MAGUK (membrane-associated guanylate kinase homolog). The mammalian homolog of dlg, SAP 97, is also known as hdlg-1 (human) and NE-dlg (neuronal and endocrine). The rat synaptic protein SAP 90 (also designated PSD-95) also shares homology with these proteins. MAGUKs are localized at the membrane-cytoskeleton interface and contain several distinct domains which suggest a role for these proteins in intracellular signal transduction. Interaction of hdlg-1 and NE-dlg with the tumor suppresor protein APC suggest that MAGUK proteins may also play a role in regulation of growth.

ID gène: 1739

Pathways: Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response