STAT3 anticorps (pTyr705, pTyr708)

N° du produit ABIN1449165

Détail du produit anti-STAT3 anticorps

Antigène: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Épitope: AA 703-714, pTyr705, pTyr708

Reactivité: Humain, Souris, Poisson zèbre (Danio rerio)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAT3 est non-conjugé

Application: Western Blotting (WB)

Séquence: CVTQPpYLKT KFI

Specificité: This antibody reacts with human and mouse STAT3 phosphorylated at Tyr705, and zebrafish STAT3 phosphorylated at Tyr708.

Purification: Protein-A Sepharose

Immunogène: 12 amino acids peptide (a.a. 703~714) which contained the phosphorylated Tyr708 of zebrafish STAT3

Clone: PS3-1

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur STAT3

Antigène: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Autre désignation: STAT3 (STAT3 Produits)

Synonymes: anticorps 1110034C02Rik, anticorps AW109958, anticorps Aprf, anticorps APRF, anticorps HIES, anticorps Xstat3, anticorps aprf, anticorps hies, anticorps stat3, anticorps wu:fc15d02, anticorps wu:fl59g06, anticorps z-Stat3, anticorps signal transducer and activator of transcription 3, anticorps signal transduction and activation of transcription 3, anticorps signal transducer and activator of transcription 3, gene 1 L homeolog, anticorps signal transducer and activator of transcription 3 (acute-phase response factor), anticorps STAT3, anticorps stat3, anticorps Stat3, anticorps stat3.1.L

Sujet: STAT (Signal Transducers and Activators of Transcription) proteins play important roles in development, cell differentiation, and cell cycle control. STAT3 is an ~85 kDa protein involved in the signaling pathways of many cytokines and growth factors, including GCSF and IL-6, where it functions as a negative regulator of transcription. STAT3 is also constitutively activated in a number of human tumors and it possesses anti-apoptotic activity and oncogenic potential. STAT3 may also regulate apoptosis by inhibiting NF?B. Activation of STAT3 by tyrosine phosphorylation results in dimerization, nuclear translocation, and DNA binding.Synonyms: APRF, Acute-phase response factor, STAT-3, Signal transducer and activator of transcription 3

ID gène: 6774

NCBI Accession: NP_003141

UniProt: P40763

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor