APP anticorps (AA 18-38)
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- Antigène Voir toutes APP Anticorps
- APP (Amyloid beta (A4) Precursor Protein (APP))
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Épitope
- AA 18-38
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp APP est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LEVPTDGNAG LLAEPQIAMF C
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse
- Purification
- Protein A agarose
- Immunogène
- Synthetic peptide corresponding to APP695 (18-38 aa)
- Clone
- 3-00E-009
- Isotype
- IgG1
- Top Product
- Discover our top product APP Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- Restore with 100 μL of distilled water.
- Buffer
- PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
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- Antigène
- APP (Amyloid beta (A4) Precursor Protein (APP))
- Autre désignation
- Amyloid beta A4 Protein / APP (APP Produits)
- Synonymes
- anticorps AAA, anticorps ABETA, anticorps ABPP, anticorps AD1, anticorps APPI, anticorps CTFgamma, anticorps CVAP, anticorps PN-II, anticorps PN2, anticorps aaa, anticorps abeta, anticorps abpp, anticorps ad1, anticorps appi, anticorps ctfgamma, anticorps cvap, anticorps pn2, anticorps APP, anticorps APP-like, anticorps APPL, anticorps Abeta, anticorps BcDNA:GH04413, anticorps CG7727, anticorps Dmel\\CG7727, anticorps EG:65F1.5, anticorps appl, anticorps Abpp, anticorps Adap, anticorps Ag, anticorps Cvap, anticorps E030013M08Rik, anticorps betaApp, anticorps app, anticorps wu:fj34d10, anticorps wu:fk65e12, anticorps zgc:85740, anticorps amyloid beta precursor protein, anticorps amyloid beta (A4) precursor protein, anticorps beta amyloid protein precursor-like, anticorps amyloid beta (A4) precursor protein a, anticorps amyloid beta precursor protein L homeolog, anticorps APP, anticorps app, anticorps Appl, anticorps App, anticorps appa, anticorps app.L
- Sujet
- Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
- ID gène
- 351
- NCBI Accession
- NP_000475
- UniProt
- P05067
- Pathways
- Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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